BDBM50156055 2-(Diphenyl-methanesulfinyl)-acetamide::2-(benzhydrylsulfinyl)acetamide::2-[(diphenylmethyl)sulfinyl]acetamide::Ambrisentan::CEP-1538::CHEMBL1373::CRL-40476::MODAFINIL::Provigil::US10913711, Compound (+-)-modafinilb::US11555013, Compound (+-)-modafinilb::US9862679, Compound (+-)-modafinil
SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
InChI Key InChIKey=YFGHCGITMMYXAQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 35 hits for monomerid = 50156055
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of rat DATMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of re-uptake of [3H]-dopamine at human DAT expressed in HEK293 cells preincubated for 5 mins followed by [3H]-dopamine addition measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.84E+5nMAssay Description:Inhibition of re-uptake of [3H]MPP+ at human NET expressed in HEK293 cells preincubated for 5 mins followed by [3H]-dopamine addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of rat brain DAT assessed as reduction of [3H]-DA re-uptake preincubated for 30 mins followed by [3H]-DA addition measured after 5 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of rat SERT-mediated serotonin reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 6.39E+4nMAssay Description:Inhibition of rat NET-mediated norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of rat DAT-mediated dopamine reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat brain NET assessed as reduction of [3H]-NE re-uptake preincubated for 30 mins followed by [3H]-NE addition measured after 5 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Displacement of 3H-WIN-35428 from DAT in rat striata after 120 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of rat DATMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of rat DAT-mediated dopamine reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 6.39E+4nMAssay Description:Inhibition of rat NET-mediated norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of rat SERT-mediated serotonin reuptakeMore data for this Ligand-Target Pair
Affinity DataKi: 927nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.52E+3nMAssay Description:Dopamine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quick...More data for this Ligand-Target Pair
Affinity DataKi: 2.52E+3nMAssay Description:Dopamine Transporter Binding Assay. Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quick...More data for this Ligand-Target Pair
Affinity DataKi: 2.52E+3nMAssay Description:Brains from male Sprague-Dawley rats weighing 200-225 g (Taconic Labs) were removed, striatum dissected and quickly frozen. Membranes were prepared b...More data for this Ligand-Target Pair
Affinity DataKi: 2.52E+3nMAssay Description:Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.60E+3nMAssay Description:Displacement of [3H]WIN35,428 from Sprague-Dawley rat brain DAT after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMAssay Description:Binding affinity to human DAT A480T mutant expressed in African green monkey COS7 cells assessed as inhibition of [3H]-dopamine uptake after 5 mins b...More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+3nMAssay Description:Inhibition of high affinity uptake by the dopamine transporter from rat synaptosomal nerve endings by using [3H]DA as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 8.16E+3nMAssay Description:Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat striatum membranes incubated for 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 8.16E+3nMAssay Description:Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat striatal membranes incubated for 120 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of high affinity uptake by the norepinephrine transporter from rat synaptosomal nerve endings by using [3H]NE as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+4nMAssay Description:Binding affinity to wild type human DAT expressed in African green monkey COS7 cells assessed as inhibition of [3H]-dopamine uptake after 5 mins by b...More data for this Ligand-Target Pair
Affinity DataKi: 3.13E+4nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat midbrain membranes incubated for 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.13E+4nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat midbrain membranes incubated for 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 3.90E+4nMAssay Description:Displacement of [3H]-N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation co...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 5.70E+5nMAssay Description:Binding affinity to human SERT T497A mutant expressed in African green monkey COS7 cells assessed as inhibition of [3H]-serotonin uptake after 3 mins...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation c...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-N-methylspiperone from human D4.4 receptor expressed in HEK293 cell membranes measured after 60 mins by microbeta scintillation ...More data for this Ligand-Target Pair