BindingDB BDBM25761 Anapriline::Avlocardyl::CHEMBL27::PROPANOLOL(-)::PROPRANOLOL, d::PROPRANOLOL, l-::PROPRANOLOL,(+)::PROPRANOLOL,(-)::Propanolol::Propanolol,(+/-)::Propranolol::[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

BDBM25761 Anapriline::Avlocardyl::CHEMBL27::PROPANOLOL(-)::PROPRANOLOL, d::PROPRANOLOL, l-::PROPRANOLOL,(+)::PROPRANOLOL,(-)::Propanolol::Propanolol,(+/-)::Propranolol::[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

SMILES CC(C)NCC(O)COc1cccc2ccccc12

InChI Key InChIKey=AQHHHDLHHXJYJD-UHFFFAOYSA-N

Data 81 KI 59 IC50 34 Kd 26 EC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 200 hits for monomerid = 25761

Beta-1 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 6.90nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 0.830nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 117nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 2.40nMAssay Description:Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pigMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 8.70nMAssay Description:Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atriaMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 2nMAssay Description:Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparationMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 1.70nMAssay Description:In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 2.40nMAssay Description:Beta-1 adrenergic receptor blocking activity in atria of guinea pig.More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 3.10nMAssay Description:Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 17nMAssay Description:Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogsMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 7.90nMAssay Description:Binding affinity to human adrenergic beta2 receptorMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 0.240nMAssay Description:Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence co...More data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 0.603nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 1.80nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 214nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 6nMAssay Description:Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

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Cytochrome P450 2D6(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.90E+3nMAssay Description:Inhibitory activity against recombinant human Cytochrome P450 2D6 (CYP2D6) after incubated for 45 minutesMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
Jagiellonian University

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.80E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair

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Sodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 2.10E+3nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
Jagiellonian University

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.80E+4nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 2.83E+3nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair

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Bile salt export pump(Human)
Astrazeneca

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair

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Bile salt export pump(Rat)
Astrazeneca

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1C(Human)
Jagiellonian University

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 2.10E+4nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C sub...More data for this Ligand-Target Pair

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Cytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 18nMAssay Description:Tested for beta1-receptor selectivity in canine cardiac tissue in anesthetized dogsMore data for this Ligand-Target Pair

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ATP-dependent translocase ABCB1(Human)
Bulgarian Academy of Sciences

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 5.73E+5nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair

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Beta-3 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 162nMAssay Description:Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence corr...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Human)
University of Nottingham

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 200nMAssay Description:Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluoresce...More data for this Ligand-Target Pair

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Beta-1 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 35nMAssay Description:Inhibitory activity against beta-1 adrenergic receptor in guinea pig atria is determinedMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 4.37E+5nMAssay Description:Binding affinity to human serum albumin by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 3.55E+5nMAssay Description:Binding affinity to 50 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 6.61E+5nMAssay Description:Binding affinity to 100 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 6.03E+5nMAssay Description:Binding affinity to 300 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 4.37E+5nMAssay Description:Binding affinity to 100 uM human serum albumin at 50 uM by PAMPA methodMore data for this Ligand-Target Pair

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Albumin(Human)
Universitat De Barcelona

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 6.31E+5nMAssay Description:Binding affinity to 600 uM human serum albumin at 10 uM by PAMPA methodMore data for this Ligand-Target Pair

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Solute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 6.32E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 3.39nMAssay Description:The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pigMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 43.6nMAssay Description:Antagonist activity of compound against Beta-2 adrenergic receptor in isolated guinea pig tracheaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 1.26nMAssay Description:Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparationMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 3.02nMAssay Description:In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tr...More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 29nMAssay Description:Inhibitory activity against beta-2 adrenergic receptor in guinea pig tracheal strip is determinedMore data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Guinea pig)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 3.39nMAssay Description:Beta-2 adrenergic receptor blocking activity in trachea of guinea pig.More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

Kd: 1.78nMAssay Description:Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB)More data for this Ligand-Target Pair

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3D Structure (crystal)

Beta-1/Beta-2/Beta-3 adrenergic receptor(Rat)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 30nMAssay Description:Inhibitory concentration required for displacement of Beta adrenergic receptor specific ligand [3H]dihydroalprenolol from rat brain cerebral cortical...More data for this Ligand-Target Pair

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3D Structure (crystal)

Sodium/bile acid cotransporter(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 5.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Human)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 4nMAssay Description:Concentration effective against displacing [3H]dihydroalprenolol from beta adrenergic receptor from canine ventricular tissueMore data for this Ligand-Target Pair

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Beta-1/Beta-2/Beta-3 adrenergic receptor(Human)
TBA

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 12nMAssay Description:Tested for Beta Adrenergic receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized...More data for this Ligand-Target Pair

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Bile salt export pump(Human)
Astrazeneca

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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Bile salt export pump(Human)
Astrazeneca

Curated by ChEMBL

PNG

BDBM25761(Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(...)

IC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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Targets 54▿
- Beta-2 adrenergic receptor 34
- Beta-1 adrenergic receptor 27
- 5-hydroxytryptamine receptor 1B 16
- D(2) dopamine receptor 7
- Beta-1/Beta-2/Beta-3 adrenergic receptor 6
- Albumin 6
- 5-hydroxytryptamine receptor 1A 6
- D(1A) dopamine receptor 5
- Voltage-dependent L-type calcium channel subunit alpha-1C 5
- Bile salt export pump 5
- Alpha-2C adrenergic receptor 4
- Alpha-1A adrenergic receptor 4
- Beta-3 adrenergic receptor 4
- Nuclear receptor subfamily 2 group E member 1 4
- 5-hydroxytryptamine receptor 2C 4
- 5-hydroxytryptamine receptor 7 4
- 5-hydroxytryptamine receptor 2A 3
- 5-hydroxytryptamine receptor 6 3
- Vasopressin V1a receptor 2
- Endothelin-1 receptor 2
- 5-hydroxytryptamine receptor 5A 2
- Muscarinic acetylcholine receptor M3 2
- Cholecystokinin receptor type A 2
- Muscarinic acetylcholine receptor M2 2
- Muscarinic acetylcholine receptor M1 2
- ATP-dependent translocase ABCB1 2
- Type-1 angiotensin II receptor 2
- Kappa-type opioid receptor 2
- Adenosine receptor A3 2
- 5-hydroxytryptamine receptor 2B 2
- Delta-type opioid receptor 2
- Cytochrome P450 2D6 2
- Mu-type opioid receptor 2
- Alpha-2A adrenergic receptor 2
- Adenosine receptor A2a 2
- Sodium-dependent serotonin transporter 1
- Solute carrier family 22 member 1 1
- 5-hydroxytryptamine receptor 5B 1
- Cytochrome P450 2J2 1
- Potassium voltage-gated channel subfamily H member 2 1
- Sodium channel protein type 5 subunit alpha 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Cytochrome P450 1A2 1
- D(3) dopamine receptor 1
- Sodium/bile acid cotransporter 1
- Histamine H1 receptor 1
- Cytochrome P450 2C9 1
- 5-hydroxytryptamine receptor 3A 1
- Cytochrome P450 2C19 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Cytochrome P450 2C8 1
- Cytochrome P450 3A4 1
- ...
Publications 50▿
- J Med Chem 58: 9287-95 (2015) 55
- Neuropharmacology 33: 275-317 (1994) 8
- J Med Chem 54: 6874-87 (2011) 7
- NIDA Res Monogr 178: 440-66 (1998) 6
- Jpn J Pharmacol 52: 195-200 (1990) 6
- J Pharmacol Exp Ther 270: 665-74 (1994) 6
- J Med Chem 51: 2009-17 (2008) 6
- J Med Chem 59: 5780-9 (2016) 4
- Toxicol Sci 136: 216-41 (2013) 4
- J Med Chem 64: 8727-8738 (2021) 4
- J Med Chem 32: 859-63 (1989) 3
- Naunyn Schmiedebergs Arch Pharmacol 369: 151-9 (2004) 3
- J Med Chem 33: 2883-91 (1990) 3
- Bioorg Med Chem 27: 2959-2971 (2019) 3
- Br J Pharmacol 144: 317-22 (2005) 3
- Cardiovasc Res 91: 53-61 (2011) 3
- J Med Chem 36: 3077-86 (1993) 2
- Psychopharmacology (Berl) 124: 57-73 (1996) 2
- J Med Chem 27: 1291-4 (1984) 2
- Mol Pharmacol 12: 568-80 (1976) 2
- J Med Chem 63: 8458-8470 (2020) 2
- Mol Pharmacol 13: 454-73 (1977) 2
- J Med Chem 45: 5671-86 (2002) 2
- Bioorg Med Chem 22: 234-46 (2014) 2
- J Med Chem 61: 5380-5394 (2018) 2
- Life Sci 19: 69-76 (1976) 2
- Drug Metab Dispos 40: 130-8 (2011) 2
- J Pharmacol Exp Ther 253: 461-5 (1990) 2
- Mol Pharmacol 43: 313-9 (1993) 2
- J Med Chem 25: 1408-12 (1983) 2
- J Med Chem 27: 857-61 (1984) 2
- J Med Chem 26: 950-7 (1983) 2
- J Appl Toxicol 32: 858-66 (2012) 2
- J Med Chem 24: 994-8 (1982) 2
- J Pharmacol Exp Ther 241: 1092-8 (1987) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- J Med Chem 23: 620-4 (1980) 2
- EMBO J 11: 4779-86 (1992) 1
- J Med Chem 36: 3161-5 (1993) 1
- J Med Chem 40: 4415-9 (1998) 1
- J Pharmacol Exp Ther 291: 1204-9 (1999) 1
- J Med Chem 30: 788-92 (1987) 1
- J Med Chem 32: 183-92 (1989) 1
- Medicinal Chemistry Research 17: 507-514 (2008) 1
- J Med Chem 33: 171-8 (1990) 1
- J Pharmacol Exp Ther 247: 169-73 (1988) 1
- Neuropsychopharmacology 3: 349-60 (1990) 1
- Brain Res 304: 1-7 (1984) 1
- Bioorg Med Chem Lett 15: 3816-20 (2005) 1
- Biochem Biophys Res Commun 184: 752-9 (1992) 1
- ...
Institutions 37▿
- Janssen Pharmaceutica 55
- TBA 21
- University of Nottingham 10
- University of Alberta 8
- Niigata College of Pharmacy 6
- Ohio State University 6
- Sri International 6
- Universitat De Barcelona 6
- Novartis Institutes For Biomedical Research 4
- Amgen 4
- Goethe-University Frankfurt 4
- Virginia Commonwealth University 3
- Berlex Laboratories 3
- University of Oxford 3
- UniversitÄT WÜRzburg 3
- Cnrs 3
- Friedrich-Alexander Universit£T Erlangen-N£Rnberg 3
- Marion Merrell Dow 2
- Astrazeneca 2
- University of Pennsylvania 2
- Jagiellonian University 2
- University of Pisa 2
- University of Florence 2
- University of California 2
- Institute For Advanced Chemistry of Catalonia (Iqac-Csic) 2
- Bulgarian Academy of Sciences 2
- Janssen Research Foundation 2
- Medical University of Lublin 2
- Sorbonne University 1
- Mayo Foundation 1
- Veterans Affairs Medical Center 1
- Vanderbilt University School of Medicine 1
- Pennwalt 1
- Bristol-Myers Squibb Pharmaceutical Research Institute 1
- Vanderbilt University 1
- Medical College of Virginia/Virginia Commonwealth University 1
- The Medical University of Warsaw 1
- ...
Affinity: 0.010 to 1.0E+6 nM▿
- Ki 81
- IC50 59
- Kd 34
- EC50 26
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1