BDBM78434 2-chloranyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;ethane-1,2-disulfonic acid::2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;ethane-1,2-disulfonic acid::2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;ethane-1,2-disulfonic acid::2-chloro-10-[3-(4-methylpiperazino)propyl]phenothiazine;ethane-1,2-disulfonic acid::Compazine::Compro::MLS001148133::PROCHLORPERAZINE::SMR000653454::cid_91499

SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1

InChI Key InChIKey=WIKYUJGCLQQFNW-UHFFFAOYSA-N

Data  31 KI  13 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 78434   

TargetNeutrophil cytosol factor 1 [S99G](Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTrypanothione reductase(Trypanosoma brucei brucei)
Univ Paris Sud

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of Trypanosoma brucei TryRMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPleiotropic ABC efflux transporter of multiple drugs(Baker's yeast)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 4.96E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 3.77E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetMitochondrial import inner membrane translocase subunit TIM10(Baker's yeast)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 2.91E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(3) dopamine receptor(Human)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  5.01nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  5.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  7.14nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  14.9nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  18.9nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  23.8nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  24nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  35nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  79.4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  122nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  148nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  196nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  540nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  556nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.13E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.69E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi:  5.88E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM78434(2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phen...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed