BDBM50241343 (RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole::(omeprazole)5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole::2-(3-methoxy-2,4-dimethylbenzylsulfinyl)-6-methoxy-1H-benzo[d]imidazole::5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole::5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole (omeprazole)::5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole(omeprazole)::5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole::5-methoxy-2-(2-(4-methoxy-3,5-dimethylpyridin-2-yl)ethylsulfinyl)-1H-benzo[d]imidazole::6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole::CHEMBL1503::ESOMEPRAZOLE SODIUM::H-168/68::OMEPRAZOLE::Omeprazole (OMP)::Prilosec::cid_4594

SMILES COc1ccc2nc([nH]c2c1)S(=O)Cc1ncc(C)c(OC)c1C

InChI Key InChIKey=SUBDBMMJDZJVOS-UHFFFAOYSA-N

Data  2 KI  20 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50241343   

TargetBombesin receptor subtype-3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLI...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.80E+3nMpH: 7.4Assay Description:Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 250nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 280nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Institute of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 1.77E+4nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 2.24E+4nMAssay Description:Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparationsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Institute of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 8.90E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Institute of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 9.12E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Institute of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 9.72E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.14E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 370nMAssay Description:Inhibition of [14C]aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 2B10(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 2B7(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1-6(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 1.85E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A4(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataIC50: 5.60E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional cytochrome P450/NADPH--P450 reductase [A82F,F87V](Bacillus megaterium)
University of Manchester

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKd:  212nMpH: 7.0Assay Description:Dissociation constants (Kd values) for binding of the substrates N-palmitoylglycine (NPG) and omeprazole (OMP) to WT and mutant BM3 heme domains were...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional cytochrome P450/NADPH--P450 reductase [F87V](Bacillus megaterium)
University of Manchester

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKd:  4.90E+4nMpH: 7.0Assay Description:Dissociation constants (Kd values) for binding of the substrates N-palmitoylglycine (NPG) and omeprazole (OMP) to WT and mutant BM3 heme domains were...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional cytochrome P450/NADPH--P450 reductase [A82F](Bacillus megaterium)
University of Manchester

LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKd:  1.67E+3nMpH: 7.0Assay Description:Dissociation constants (Kd values) for binding of the substrates N-palmitoylglycine (NPG) and omeprazole (OMP) to WT and mutant BM3 heme domains were...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFatty acid synthase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50241343(H-168/68 | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylp...)
Affinity DataKi:  4.50E+4nMAssay Description:Binding affinity towards cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed