BDBM50116766 (-)-Pramipexole::(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine::2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-::CHEMBL301265::PRAMIPEXOLE::cid_119570
SMILES CCCN[C@H]1CCc2nc(N)sc2C1
InChI Key InChIKey=FASDKYOPVNHBLU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 107 hits for monomerid = 50116766
TargetCystic fibrosis transmembrane conductance regulator(Human)
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay
Affinity DataEC50: 1.5nMAssay Description:Effective concentration required for agonistic activity against human D3 receptorMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 9.20nMAssay Description:Effective concentration required for agonistic activity against rat D2 short receptorMore data for this Ligand-Target Pair
Affinity DataKd: 1.60nMAssay Description:Binding affinity of compound against Dopamine receptor D2 was measured using [3H]pramipexole in Bovine striatal membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Effective concentration required for agonistic activity against human D4.2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2S mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.20nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2L mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Effective concentration to stimulate human Dopamine receptor D4.2 mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligand;...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Effective concentration against dopamine D3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human D2 dopamine receptor expressed in CHO cell membrane by GTPgammaS-binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Effective concentration required for agonistic activity against rat D2 short receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibitory concentration against [3H]- spiperone binding to Dopamine receptor at 10 mg/kgMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
Affinity DataEC50: 9.60nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at Rattus norvegicus (rat) dopamine D2 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-s...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
Affinity DataEC50: 5.40nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 an...More data for this Ligand-Target Pair
Affinity DataKd: 0.0149nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 14...More data for this Ligand-Target Pair
Affinity DataKd: 0.0149nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK at high concentr...More data for this Ligand-Target Pair
Affinity DataKd: 0.0258nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 min...More data for this Ligand-Target Pair
Affinity DataEC50: 166nMAssay Description:Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing NlucN-mGs/hH2R-NlucC assessed as induction of mini-Gi...More data for this Ligand-Target Pair
Affinity DataEC50: 6.5nMAssay Description:Agonist activity at human D2 long receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD2longR-ElucC by beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 0.813nMAssay Description:Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.5nMAssay Description:Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incuba...More data for this Ligand-Target Pair
Affinity DataEC50: 251nMAssay Description:Agonist activity at human D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by Perkin elmer analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 4.10nMAssay Description:Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by Perkin elmer analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity to human D3 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.661nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 min...More data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatumMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]-R(+)-7-OHDPAT from dopamine D3 receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 0.870nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 0.87/44)More data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:High inhibition constant against [3H]spiperone binding to human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:High binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.940nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scin...More data for this Ligand-Target Pair