BDBM50148732 17-ethynyl-17beta-hydroxyestr-4-en-3-one::17alpha-ethinyl-19-nortestosterone::17alpha-ethinylestra-4-en-17beta-ol-3-one::17alpha-ethynyl-19-nor-4-androsten-17beta-ol-3-one::17beta-hydroxy-19-norpregn-4-en-20-yn-3-one::19-Nor-17alpha-ethynyl-17beta-hydroxy-4-androsten-3-one::19-Norethisterone::19-nor-17alpha-ethynyltestosterone::4-estren-17alpha-ethynyl-17beta-ol-3-one::CHEMBL1162::Micronor::NORETHINDRONE::Norethisteron::Primolut-N::norethisterone

SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C

InChI Key InChIKey=VIKNJXKGJWUCNN-UHFFFAOYSA-N

Data  1 KI  4 IC50  3 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50148732   

TargetProgesterone receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataKd:  0.400nMAssay Description:Dissociation constant for progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProgesterone receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProgesterone receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataEC50:  2.20nMAssay Description:Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSex hormone-binding globulin(Human)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataKd:  11nMAssay Description:Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAndrogen receptor(Rat)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstrogen receptor beta(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataKd:  0.630nMAssay Description:Equilibrium dissociation constant for rat uterine estrogen receptor binding [3H]estradiolMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148732(17alpha-ethinyl-19-nortestosterone | 17alpha-ethin...)
Affinity DataKi:  1.90nMAssay Description:The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)