BDBM15296 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile::6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile::CHEMBL189::Milrinone::Primacor::US9242982, Milrinone::US9249139, Milrinone
SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
InChI Key InChIKey=PZRHRDRVRGEVNW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 60 hits for monomerid = 15296
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.10E+5nMAssay Description:Inhibition of cAMP-phosphodiesterase PDE 1 from guinea pig, range 190-430More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.10E+5nMAssay Description:Inhibition of cAMP PDE I enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of cAMP PDE III enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of cAMP PDE II enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of PDE 3 (phosphodiesterase III) from guinea pig ventricleMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Phosphodiesterase 3 from human platelets at 1E-7-1E-4M or 1.0E-6 to 1E-3 MMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of canine Phosphodiesterase III (PDE 3)More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.98E+5nMAssay Description:Inhibition of canine PDE1More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/Phosphodiesterase(Rat)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 1 (PDE I)More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:In vivo inhibition of cyclic AMP phosphodiesterase from human plateletsMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibition of cGMP phosphodiesterase PDE 1 from guinea pig, range 170-510More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of cAMP-phosphodiesterase PDE 3 from guinea pig, range 1.9-3.1More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibition cGMP PDE I enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of cGMP phosphodiesterase PDE 2 from guinea pig, range 120-290More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of canine cardiac cAMP phosphodiesterase (cAMP-PDE)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Cardiotonic effect by inhibition of cAMP phosphodiesterase (PDE III)More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of cAMP Phosphodiesterase 3More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of fraction III of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:In vitro inhibitory activity against cAMP phosphodiesterase III in dog aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of guinea pig ventricular Phosphodiesterase 3More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of human platelet PDE3More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of PDE3 by Biomol Green quantizyme assay systemMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant PDE3A using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Baruch S. Blumberg Institute
Curated by ChEMBL
The Baruch S. Blumberg Institute
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant PDE3 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMT: 2°CAssay Description:PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood we...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMT: 2°CAssay Description:PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood we...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of cGMP PDE II enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibitory concentration against cAMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibitory activity against cGMP-phosphodiesterase from porcine aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of cGMP phosphodiesterase PDE 2 from guinea pig, range 27-41More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.10E+5nMAssay Description:Inhibitory concentration against cAMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed as cAMP hydrolysis after 60 mins by fluorescence polarization assay using fluorescein-tagged cAMP as s...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of thrombin-induced platelet aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 843nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 0.581-1.23More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory concentration against cGMP PDE II enzyme in guinea pigMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibitory concentration against cGMP PDE I enzyme in guinea pigMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against cAMP PDE III enzyme in guinea pigMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 2 (PDE2) from porcine plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 10.4-16.3More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 3More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 5More data for this Ligand-Target Pair