BDBM50260270 CHEMBL506986::KwFwLL-NH2

SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O

InChI Key InChIKey=ZGQSDHNDIKTEJD-UHFFFAOYSA-N

Data  2 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50260270   

TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataIC50: 36nMAssay Description:Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataIC50: 13nMAssay Description:Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively st...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataEC50:  100nMAssay Description:Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataEC50:  45.6nMAssay Description:Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataEC50:  100nMAssay Description:Inverse agonist activity at GHS-R1a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataKi:  255nM ΔG°:  -8.99kcal/moleT: 2°CAssay Description:Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50260270(KwFwLL-NH2 | CHEMBL506986)
Affinity DataKi:  255nMAssay Description:Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed