BDBM50252513 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one::9-OH-risperidone::9-hydroxy risperidone::CHEMBL1621::Invega::PALIPERIDONE

SMILES Cc1nc2C(O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12

InChI Key InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N

Data  69 KI  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50252513   

LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of long-lasting type calcium current (ICaL) in HEK293 cells (alpha1C/beta2a/alpha2delta1) cells measured using IonWorks Barracuda automat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 3.98E+5nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonW...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily D member 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.220nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.21nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Mouse)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  3.90nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  4.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  6.90nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  9.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  10.1nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(4) dopamine receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  30nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50252513(9-OH-risperidone | Invega | CHEMBL1621 | 9-hydroxy...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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