BDBM50017698 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide::4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide::4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide(loperamide)::CHEMBL841::Imodium::LOPERAMIDE::LOPERAMIDE HYDROCHLORIDE::cid_71420::med.21724, Compound 184

SMILES CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=RDOIQAHITMMDAJ-UHFFFAOYSA-N

Data  11 KI  16 IC50  2 Kd  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50017698   

TargetATP-dependent translocase ABCB1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 2.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCocaine esterase(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of hCES2A in human liver microsome assessed as reduction in fluorescein diacetate hydrolysis preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCocaine esterase(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human CE2 using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  5.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  4.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
University of Bonn

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  4.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  5.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  4.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 9.27E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMenin(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 6.90E+4nMAssay Description:Displacement of FITC-MBM1 from full length human menin measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 239nMAssay Description:Inhibition of human Nav1.5 channel expressed in HEK293 cells at holding potential of -70 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCocaine esterase(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Zhejiang Gongshang University

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKd:  5.90E+3nMAssay Description:Binding affinity to human recombinant Tie2 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 22 member 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 2.37E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 270nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin(Bovine)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 1.20E+4nMAssay Description:Displacement of [3H]trifluoperazine from bovine brain CaM in presence of calciumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin(Bovine)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKd:  3.50E+3nMAssay Description:Binding affinity to bovine brain CaM by FTPFACE analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 155nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 123nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  156nMAssay Description:Inhibition of delta opioid receptor mediated GTPgammaS binding to CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  58nMAssay Description:Inhibition of mu opioid receptor mediated GTPgammaS binding to CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataIC50: 3.50E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetMu-type opioid receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  0.268nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  0.530nMAssay Description:Binding affinity for recombinant human mu-opioid receptor was determined by using [3H]- diprenophine radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  50nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  127nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  205nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCocaine esterase(Human)
Shanghai University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human CES2A using 4-methylumbelliferone as a substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  1.94E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi:  5.79E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNociceptin receptor(Human)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity for opioid receptor like 1 expressed in HEK293 cells More data for this Ligand-Target Pair
In DepthDetails Article
PubMed