BDBM50340678 1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluorouracil::2'-deoxy-5-fluorouridine::5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione::5-Fluoro-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione::5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione::5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione::5-fluoro-2'-Deoxy-uridine::5-fluoro-2'-deoxyuridine::CHEMBL917::FLOXURIDINE::FUDR::Fluoruridine Deoxyribose

SMILES OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

InChI Key InChIKey=ODKNJVUHOIMIIZ-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50340678   

TargetSodium/nucleoside cotransporter 2(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human CNT2 expressed in COS7 cells assessed as reduction in sodium-dependent [14C]-inosine uptake in presence of Na+ by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 h...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 43nMAssay Description:Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 20nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient /TK cells after 2 hr treatmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 260nMAssay Description:Thymidylate synthase inhibition in wild type LM cells after 2 hr treatmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 5.40E+3nMAssay Description:Thymidylate synthase inhibition in thymidine kinase deficient LM cells after 2 hr treatmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 7.90nMAssay Description:Thymidylate synthase inhibition in L1210 mouse leukemia cells after 2 hr treatmentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 15 member 1(Human)
Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50340678(1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluoro...)
Affinity DataIC50: 1.22E+7nMAssay Description:Substrate activity at PEPT1 (unknown origin) expressed in MDCK cells assessed as inhibition of gly-sar uptake incubated for 10 mins by HPLC/MS/MS ana...More data for this Ligand-Target Pair
In DepthDetails
PubMed