BDBM50127140 (-)-etoposide::(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside::4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)::4-demethylepipodophyllotoxin beta-D-ethylideneglucoside::9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one::CHEMBL44657::Etoposide (ET)::TRANS-ETOPOSIDE::VP-16::etoposide
SMILES COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12
InChI Key InChIKey=VJJPUSNTGOMMGY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 61 hits for monomerid = 50127140
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 3.80E+4nMAssay Description:In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA controlMore data for this Ligand-Target Pair
3D Structure (crystal)TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 810nMAssay Description:Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 810nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 810nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 810nMAssay Description:Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5.02E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of topoisomerase 2More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 5.04E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 5.60E+4nMAssay Description:Concentration of compound at which inhibitory activity detected against DNA topoisomerase IIMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 7.84E+4nMAssay Description:Inhibition of human topoisomerase-2alpha using kDNA as substrate assessed as inhibition of ATP-dependent kDNA decatenation after 30 mins by agarose g...More data for this Ligand-Target Pair
Affinity DataIC50: 2.82E+4nMAssay Description:Inhibition of human DNA topoisomerase-2alpha assessed as relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.75E+4nMAssay Description:Inhibition of human topo2alpha incubated for 30 mins by SYBR safe DNA stain based decatenation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.38E+4nMAssay Description:Inhibition of recombinant human topoisomerase 2alpha using supercoiled pNO1 plasmid as substrate after 30 mins by SYBR-GOLD staining based fluorimetr...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human topoisomerase 2alpha using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence based microplate reade...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of recombinant human topoisomerase 2alpha using supercoiled pBR322 DNA as substrate incubated for 60 mins by ethidium bromide dye based ag...More data for this Ligand-Target Pair
Affinity DataIC50: 6.83E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alpha assessed as suppression of decatenation using catenated kinetoplast DNA as substrate measured after 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of human DNA topoisomerase 2 beta assessed as relaxation of supercoiled plasmid pBR322 DNA incubated for 30 mins by ethidium bromide stain...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human DNA topoisomerase 2 alpha assessed as ATP hydrolysis measured for 30 mins by absorbance based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%More data for this Ligand-Target Pair
TargetTegument protein VP16(HHV-1)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 3.59E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetNuclear receptor coactivator 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.20E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+4nMpH: 7.9Assay Description:Relaxation of negatively supercoiled plasmid DNA by human topoisomerase IIα was assayed in 20 µL of reaction buffer (10 mM Tris-HCl, pH 7.9, 150...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
Affinity DataIC50: 7.57E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alpha using plasmid pNO1 substrate incubated at 37 degC for 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B3(Human)
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Universit£Tsmedizin G£Ttingen
Curated by ChEMBL
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of human OATP1B3-mediated [3H]CCK-8 after 5 mins by Dixon plot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.84E+4nMAssay Description:Inhibition of human topoisomerase-2 alpha assessed as reduction in enzyme-mediated kinetoplast DNA decatenation incubated for 30 mins by ethidium bro...More data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 1a)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: 2.10E+5nMAssay Description:Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.03E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataEC50: >7.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
TargetNuclear receptor coactivator 3(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 2.48E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataEC50: 810nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast plasmid DNA by fluorescent plate readerMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant DNA topoisomerase1More data for this Ligand-Target Pair