BDBM50016799 (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid::2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid::AY-24236::CHEMBL622::ETODOLAC::Etodolic Acid::Lodine::Lodine xl

SMILES CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12

InChI Key InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N

Data  10 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50016799   

TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of COX2 (unknown origin) fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataIC50: 54nMAssay Description:Inhibition of COX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  940nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  2.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  2.47E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  3.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  9.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 22 member 6(Rat)
University of California

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of rat Oat1 expressed in pig LLC-PK11 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM50016799(Lodine | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,...)
Affinity DataKi:  1.80E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed