BDBM50426497 CABERGOLINE::Dostinex::FCE-21336

SMILES CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(CC=C)C1

InChI Key InChIKey=KORNTPPJEAJQIU-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50426497   

Target5-hydroxytryptamine receptor 2B(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataEC50:  13nMAssay Description:Inhibition of dopamine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM50426497(FCE-21336 | Dostinex | CABERGOLINE)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to dopamine D1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed