BDBM50131593 4-[4-Chloro-5-(3-fluoro-4-methoxy-phenyl)-imidazol-1-yl]-benzenesulfonamide::CHEMBL435381::cimicoxib

SMILES COc1ccc(cc1F)-c1c(Cl)ncn1-c1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=KYXDNECMRLFQMZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50131593   

TargetProstaglandin G/H synthase 1(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 66nMAssay Description:In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 5nMAssay Description:In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 100nMAssay Description:Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Domp&Egrove

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of COX-2 in human 143982 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed