BDBM15339 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid::6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid::Biphenquinate::Brequinar::US20240034730, Compound Brequinar
SMILES Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
InChI Key InChIKey=PHEZJEYUWHETKO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 15339
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal His-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli using DL-dihydroorotic acid as substra...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of DHODH (unknown origin) expressed in Escherichia coli Rosetta2(DE3) assessed as reduction of DCIP using dihydroorotate as substrate prei...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo
Curated by ChEMBL
Universidade De S£O Paulo
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo
Curated by ChEMBL
Universidade De S£O Paulo
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Schistosoma mansoni DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant N-terminal His-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli using L-DHO as substrate measured ever...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) assessed as inhibition of DC...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length C-terminal MYC/DDk-tagged DHODH using decylubiquinone as substrate measured for 1 hr by DCIP absorbance a...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human N-terminal GST-fusion tagged DHODH expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate at 50 u...More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Turin
Curated by ChEMBL
University of Turin
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of dihydroorotate dehydrogenase in Wistar rat liver mitochondrial/microsomal membranes measured for 5 mins by 2,6-dichlorophenolindophenol...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Turin
Curated by ChEMBL
University of Turin
Curated by ChEMBL
Affinity DataIC50: 367nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
Affinity DataIC50: 127nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 7nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of DHODH (unknown origin) using L-DHO, DUQ, DCIP as substrate preincubated for 30 mins followed by substrate addition measured after 20 mi...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human DHODH by using blue indicator dye DCIPMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHODH expressed in baculovirus infected insect cells using dihydroorotate as substrate in presence of quinone by dich...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Turin
Curated by ChEMBL
University of Turin
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of rat recombinant His-tagged truncated DHODH expressed in Escherichia coli using dihydroorotate as substrate by chromogen reduction assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Turin
Curated by ChEMBL
University of Turin
Curated by ChEMBL
Affinity DataIC50: 367nMAssay Description:Inhibition of rat purified recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human purified recombinant DHODHMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as s...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Guangxi University of Chinese Medicine
Curated by ChEMBL
Guangxi University of Chinese Medicine
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition measurement of orotate formation from radiolabeled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair