BDBM13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607

SMILES Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1

InChI Key InChIKey=LNPDTQAFDNKSHK-UHFFFAOYSA-N

Data  123 KI  31 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 162 hits for monomerid = 13063   

TargetCarbonic anhydrase 1(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5.40E+4nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 43nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 340nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 27nMpH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRas-related protein Rab-2A(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetGTPase KRas [1-37](Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetRas-related protein Rab-7a(Dog)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.40E+5nMAssay Description:In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.40E+5nMAssay Description:Compound was tested for its inhibitory activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human cyclooxygenase-1 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 3.43E+4nMAssay Description:Inhibition of COX1 in LPS-induced human whole blood assessed as PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 treated 1 hr before a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for its inhibitory activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 570nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 183nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome c oxidase subunit 1(Sheep)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 9.62E+4nMAssay Description:Inhibition of ovine cyclooxygenase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.57E+5nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 660nMAssay Description:Inhibition of COX2 in human whole blood assessed as effect on thrombin-induced TXB2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 183nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 43nMAssay Description:Inhibitory activity of compound against human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibitory activity of compound against human carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5.01nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase(Sulfurihydrogenibium sp. (strain YO3AOP1))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against cloned human CA12More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant CA12 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  27nMAssay Description:Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against cloned human CA9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  27nMAssay Description:Inhibition of human recombinant CA9 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Marburg

LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataKi:  27nMAssay Description:Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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