22 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.
Georgia State University
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Sanford-Burnham Medical Research Institute
Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.
Georgia State University
Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach.
University of Kwazulu-Natal
Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates.
Uppsala University
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
Uppsala University
Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.
Georgia State University
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
Academy of Sciences of The Czech Republic
Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
Georgia State University
Protein kinase inhibitors, preparation method and medical use thereof
Gan & Lee Pharmaceuticals
The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.
University of British Columbia
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
University of California Berkeley
Novel antagonists of the thioesterase domain of human fatty acid synthase.
Burnham Institute For Medical Research