Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Heteroaromatic compounds as BTK inhibitors

Boehringer Ingelheim International

8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives

Idorsia Pharmaceuticals

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Eisai

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

Wyeth Research

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.

Sunesis Pharmaceuticals

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.

Astrazeneca

Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.

Abbott Laboratories