PMID

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Article Title

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Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors.

University of Bonn

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

Sanford-Burnham Medical Research Institute

Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

Ku Leuven

Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(a or¿)-thio-(a,ß- orß,¿)-methylenetriphosphate scaffold.

Bar-Ilan University

Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study.

UniversitÉ

Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.

Bar-Ilan University

1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors.

University of Karachi

Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy.

Ajou University

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.

University of Sharjah

Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors.

Korea Institute of Science and Technology

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.

Comsats University Islamabad

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.

Quaid-I-Azam University

Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39.

Arcus Biosciences

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.

X-Chem

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors.

University of Sharjah

Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold.

Bar-Ilan University

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.

University of Sharjah

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile.

Quaid-I-Azam University

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P

Bar-Ilan University

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.

Laval University

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.

Universit£T Rostock

COMPOUND AS TYK2/JAK1 PSEUDOKINASE DOMAIN INHIBITOR, AND SYNTHESIS AND USE METHODS

Zhejiang Wenda Pharmaceutical Technology

IRAK4 DEGRADATION AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Shanghai Leadingtac Pharmaceutical

N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof

Chia Tai Tianqing Pharmaceutical Group

PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES

Hoffmann-La Roche

QUINOLINE COMPOUNDS

Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

Histone demethylase inhibitors

Celgene Quanticel Research

Carboxamide-pyrimidine derivatives as SHP2 antagonists

Merck Patent

6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors

Ajax Therapeutics

Condensed ring compounds having dopamine D3 receptor antagonistic effect

Shionogi

2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof

TBA

Bicyclic derivatives

Hoffmann-La Roche

4-carboxybenzylamino derivatives as histone deacetylase inhibitors

Merck Sharp & Dohme