PMID

Data

Article Title

Organization

Synthesis, antinociceptive activity, and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols.

Glaxo Group Research

Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.

University of Minnesota

Synthesis and opioid activity of dermorphin tetrapeptides bearing D-methionine S-oxide at position 2.

TBA

Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors.

TBA

Different receptor sites mediate opioid agonism and antagonism.

TBA

Stereochemical studies on medicinal agents. 25. Absolute configuration and analgetic potency of beta-1,2-dimethyl-2-phenyl-4-(propionyloxy)piperidine enantiomers.

TBA

Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.

TBA

N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.

Oregon State University

O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.

University of Washington

Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.

University of Washington

Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6 alpha- and 6 beta-naltrexol.

University of Washington

A high affinity, mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine.

University of Michigan

An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.

Predix Pharmaceuticals

Benzimidazolone-based selective σ

University of Florida

Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines.

TBA

3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents.

TBA

Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin.

TBA

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone.

TBA

Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone.

TBA

Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.

TBA

4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series.

TBA

Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids.

TBA

Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions.

TBA

N-(2-Cyanoethyl) derivatives of meperidine, ketobemidone, and a potent 6,7-benzomorphan.

TBA

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.

University of Minnesota

Design and synthesis of highly potent and selective cyclic dynorphin A analogues.

University of Arizona

Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.

University of Washington