PMID

Data

Article Title

Organization

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.

Washington University

Synthesis and in vitro evaluation ofa-synuclein ligands.

Washington University

Structure-Activity Relationships of Cyano-substituted Indole Derivatives as Ligands for α-Synuclein Aggregates.

Beijing Normal University

Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.

Zhengzhou University

Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.

Sun Yat-Sen University

Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against α-synuclein oligomers and fibrils.

Zhengzhou University

4-Arylidene curcumin derivatives in vitro inhibit α-Synuclein aggregation and disaggregate the preformed fibril.

Zhengzhou University

Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.

Sun Yat-Sen University

Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.

Csir-Indian Institute of Chemical Technology (CSIR-IICT)

Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators.

IQM-CSIC

Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives.

Universite Grenoble Alpes

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.

German University In Cairo

Hybrids of polyphenolic acids and xanthone, the potential preventive and therapeutic effects on PD: Design, synthesis, in vitro anti-aggregation of α-synuclein, and disaggregation against the existed α-synuclein oligomer and fibril.

Zhengzhou University

Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.

Fudan University

Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.

University of Catania

Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system.

Fudan University

Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation.

Zhengzhou University

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation.

Zhengzhou University

Novel Bis-heteroaryl Derivatives To Modulate Protein Aggregation for the Treatment of Neurodegenerative Diseases.

Drexel University

A routinely used protein staining dye acts as an inhibitor of wild type and mutant alpha-synuclein aggregation and modulator of neurotoxicity.

National Institute of Immunology

NOVEL DIOXANE DERIVATIVES

Boehringer Ingelheim International

Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases

Regents of The University of Colorado, A Body Corporate

Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Galapagos

USP30 inhibitors

Mitobridge

Imidazo isoindole derivative, preparation method therefor and medical use thereof

Jiangsu Hengrui Medicine

PSMA imaging agents

Siemens Medical Solutions Usa

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity.

Amgen

Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity.

University of Rochester