Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.

Virginia Tech

Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Amgen

Rational design of SphK inhibitors using crystal structures aided by computer.

Shandong First Medical University & Shandong Academy of Medical Sciences

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.

Virginia Tech

Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.

University of Virginia