Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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10 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Identification of 6-Hydroxypyrimidin-4(1

Bristol Myers Squibb

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.

Bristol Myers Squibb

Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists.

Bristol-Myers Squibb

PEGylated and Acylated Elabela Analogues Show Enhanced Receptor Binding, Prolonged Stability, and Remedy of Acute Kidney Injury.

Huazhong University of Science & Technology

Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.

University of Alberta

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.

Amgen

Identification of potent pyrazole based APELIN receptor (APJ) agonists.

Rti International

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

University of Alberta

Biphenyl Acid Derivatives as APJ Receptor Agonists.

Bristol-Myers Squibb

Synthetic Modification within the"RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

University of Alberta