PMID

Data

Article Title

Organization

(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomalß-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.

Orleans University

Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme.

The Barcelona Institute of Science and Technology

Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutantß-N-acetylhexosaminidase Activity.

Sickkids

Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.

Nankai University

Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human β-N-Acetyl-d-hexosaminidase.

East China University of Science and Technology

High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones.

Research Institute, Hospital For Sick Children

Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.

The Scripps Research Institute