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Article Title

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Identification of Ligand Binding Hot Spots of the Histamine H

Vrije Universiteit Amsterdam

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function.

Vrije Universiteit Amsterdam

Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.

Vrije Universiteit Amsterdam

Linking agonist binding to histamine H1 receptor activation.

Vrije Universiteit Amsterdam

Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.

Vrije Universiteit Amsterdam

Development of

Vrije Universiteit Amsterdam

Structural Analysis of Chemokine Receptor-Ligand Interactions.

Vrije Universiteit Amsterdam

Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.

Vrije Universiteit Amsterdam

Fragment-to-Lead Medicinal Chemistry Publications in 2020.

Vrije Universiteit Amsterdam

Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.

Vrije Universiteit Amsterdam

PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.

Vrije Universiteit Amsterdam

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H

Vrije Universiteit Amsterdam

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

Vrije Universiteit Amsterdam

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.

Vrije Universiteit Amsterdam

Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

Vrije Universiteit Amsterdam

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.

Vrije Universiteit Amsterdam

N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.

Vrije Universiteit Amsterdam

Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.

Vrije Universiteit Amsterdam

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.

Vrije Universiteit Amsterdam

Trifluoromethyl alcohols as modulators of RORγt

Janssen Pharmaceutica