PMID

Data

Article Title

Organization

Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands.

University of Trieste

5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.

University of Trieste

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

University of Trieste

Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.

University of Trieste

Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.

University of Trieste

Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor.

University of Trieste

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane baseds1 receptor ligands.

University of Trieste

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.

University of Trieste

Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives.

University of Trieste

Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.

University of Trieste

New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).

University of Trieste

Anthranilic acid based CCK1 receptor antagonists: blocking the receptor with the same 'words' of the endogenous ligand.

University of Trieste

Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site.

University of Trieste

Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.

University of Trieste

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.

University of Trieste

Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.

University of Trieste

Conjugable A

University of Trieste

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.

University of Trieste

Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.

University of Trieste

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands.

University of Trieste

Synthesis and biological activity of potent HIV-1 protease inhibitors based on Phe-Pro dihydroxyethylene isosteres.

University of Trieste

[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A

University of Trieste

New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.

University of Trieste