PMID

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Discovery of 4-((3'R,4'S,5'R)-6¿-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2¿-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3¿-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Deve

University of Michigan Comprehensive Cancer Center

LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor.

University of Michigan Comprehensive Cancer Center

AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development.

University of Michigan Comprehensive Cancer Center

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.

University of Michigan Comprehensive Cancer Center

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

University of Michigan Comprehensive Cancer Center