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Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

University Hospital Hradec Kralove

Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.

University Hospital Hradec Kralove

7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties.

University Hospital Hradec Kralove

Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.

University Hospital Hradec Kralove

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.

University Hospital Hradec Kralove

Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.

University Hospital Hradec Kralove