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3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.

Universita Degli Studi Di Firenze

The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A

Universita Degli Studi Di Firenze

Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.

Universita Degli Studi Di Firenze

Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A

Universita Degli Studi Di Firenze

Dithiocarbamates effectively inhibit theß-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.

Universita Degli Studi Di Firenze

Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.

Universita Degli Studi Di Firenze

Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.

Universita Degli Studi Di Firenze

Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties.

Universita Degli Studi Di Firenze

Bortezomib inhibits bacterial and fungalß-carbonic anhydrases.

Universita Degli Studi Di Firenze

N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.

Universita Degli Studi Di Firenze

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.

Universita Degli Studi Di Firenze

Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.

Universita Degli Studi Di Firenze

Comparison of the sulfonamide inhibition profiles of thea-,ß- and¿-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.

Universita Degli Studi Di Firenze

Anion inhibition studies of theß-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of theß-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

Universita Degli Studi Di Firenze

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.

Universita Degli Studi Di Firenze

Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.

Universita Degli Studi Di Firenze

Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.

Universita Degli Studi Di Firenze

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII.

Universita Degli Studi Di Firenze

Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.

Universita Degli Studi Di Firenze

Inhibition studies of bacterial, fungal and protozoanß-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties.

Universita Degli Studi Di Firenze

Anion inhibition study of theß-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.

Universita Degli Studi Di Firenze

a-Carbonic Anhydrases Possess Thioesterase Activity.

Universita Degli Studi Di Firenze

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

Universita Degli Studi Di Firenze

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of the¿-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.

Universita Degli Studi Di Firenze

Sulfonamides with Potent Inhibitory Action and Selectivity against thea-Carbonic Anhydrase from Vibrio cholerae.

Universita Degli Studi Di Firenze

Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis¿-carbonic anhydrase.

Universita Degli Studi Di Firenze

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Universita Degli Studi Di Firenze

A class of 4-sulfamoylphenyl-¿-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

Universita Degli Studi Di Firenze

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

Universita Degli Studi Di Firenze

Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.

Universita Degli Studi Di Firenze

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

Universita Degli Studi Di Firenze

The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.

Universita Degli Studi Di Firenze

Sulfonamide inhibition studies of thed-carbonic anhydrase from the diatom Thalassiosira weissflogii.

Universita Degli Studi Di Firenze

Anion inhibition studies of aß-carbonic anhydrase from Clostridium perfringens.

Universita Degli Studi Di Firenze

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.

Universita Degli Studi Di Firenze

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of theß-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.

Universita Degli Studi Di Firenze

Anion inhibition studies of thea-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

Universita Degli Studi Di Firenze

Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.

Universita Degli Studi Di Firenze

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.

Universita Degli Studi Di Firenze

Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.

Universita Degli Studi Di Firenze

Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

Universita Degli Studi Di Firenze

Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

Universita Degli Studi Di Firenze

The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.

Universita Degli Studi Di Firenze

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.

Universita Degli Studi Di Firenze

Carbonic anhydrases as targets for medicinal chemistry.

Universita Degli Studi Di Firenze

Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.

Universita Degli Studi Di Firenze

1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

Universita Degli Studi Di Firenze

Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.

Universita Degli Studi Di Firenze

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.

Universita Degli Studi Di Firenze

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.

Universita Degli Studi Di Firenze

5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.

Universita Degli Studi Di Firenze

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.

Universita Degli Studi Di Firenze

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.

Universita Degli Studi Di Firenze

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives.

Universita Degli Studi Di Firenze

Purification and inhibition studies with anions and sulfonamides of ana-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.

Universita Degli Studi Di Firenze

(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.

Universita Degli Studi Di Firenze

Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides.

Universita Degli Studi Di Firenze

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

Universita Degli Studi Di Firenze

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

Universita Degli Studi Di Firenze

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.

Universita Degli Studi Di Firenze

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

Universita Degli Studi Di Firenze

Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.

Universita Degli Studi Di Firenze

Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.

Universita Degli Studi Di Firenze

3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.

Universita Degli Studi Di Firenze

Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.

Universita Degli Studi Di Firenze

Discovery of first-in-class multi-target adenosine A

Universita Degli Studi Di Firenze

New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A

Universita Degli Studi Di Firenze

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A

Universita Degli Studi Di Firenze

Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.

Universita Degli Studi Di Firenze

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.

Universita Degli Studi Di Firenze

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.

Universita Degli Studi Di Firenze

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

Universita Degli Studi Di Firenze

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.

Universita Degli Studi Di Firenze

Antioxidant-Conjugated 1,2,4-Triazolo[4,3-

Universita Degli Studi Di Firenze

Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.

Universita Degli Studi Di Firenze

Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.

Universita Degli Studi Di Firenze

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

Universita Degli Studi Di Firenze

Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties.

Universita Degli Studi Di Firenze

Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition.

Universita Degli Studi Di Firenze

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.

Universita Degli Studi Di Firenze

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.

Universita Degli Studi Di Firenze

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.

Universita Degli Studi Di Firenze

A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABA

Universita Degli Studi Di Firenze

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A

Universita Degli Studi Di Firenze

Structure-activity relationship studies and pharmacological characterization of N

Universita Degli Studi Di Firenze

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

Universita Degli Studi Di Firenze

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.

Universita Degli Studi Di Firenze

Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A

Universita Degli Studi Di Firenze

Development of novel pyridazinone-based adenosine receptor ligands.

Universita Degli Studi Di Firenze

Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.

Universita Degli Studi Di Firenze

1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.

Universita Degli Studi Di Firenze

Bortezomib inhibits mammalian carbonic anhydrases.

Universita Degli Studi Di Firenze

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A

Universita Degli Studi Di Firenze

Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.

Universita Degli Studi Di Firenze

Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.

Universita Degli Studi Di Firenze

Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.

Universita Degli Studi Di Firenze

Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.

Universita Degli Studi Di Firenze

N-substituted-5-substituted phthalamic acids as sortilin inhibitors

H. Lundbeck

Substituted 2-azabicycles and their use as orexin receptor modulators

Janssen Pharmaceutica

Pyridine compounds and the uses thereof

Purdue Pharma

Histone demethylase inhibitors

Celgene Quanticel Research

Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives

Revivia Pharmaceuticals

Compounds having TRPV1 antagonistic activity and uses thereof

Shionogi

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

Plexxikon

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.

Chinese Academy of Sciences

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.

Institut Curie

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.

Parke-Davis Pharmaceutical Research

Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

University of Auckland

Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

University of Auckland