PMID

Data

Article Title

Organization

Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors

The University of Rochester

Dihydropyrrolopyridine inhibitors of ROR-gamma

Vitae Pharmaceuticals

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.

Glaxosmithkline

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues.

Bristol-Myers Squibb

Antibacterial agent discovery using thymidylate synthase biolibrary screening.

Unimore

Ketopiperazine-based renin inhibitors: optimization of the "C" ring.

Pfizer

The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors.

Pfizer

Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.

Boehringer Ingelheim Pharma

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

The Institute For Diabetes Discovery

A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.

Pfizer

Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.

Medical College of Wiscosin

Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.

University of Marburg

Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.

University of Marburg

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design.

Astex

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.

Astex

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

Janssen Research Foundation