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Article Title

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Similarity- and Substructure-Based Development ofß

Philipps University Marburg

First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.

Philipps University Marburg

New Insights into Human 17ß-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor.

Philipps University Marburg

Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: Crystal Structures and Residual Hydration Patterns Suggest Why.

Philipps University Marburg

Development of new cyclic plasmin inhibitors with excellent potency and selectivity.

Philipps University Marburg

Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.

Philipps University Marburg

A new strategy for the development of highly potent and selective plasmin inhibitors.

Philipps University Marburg

New substrate analogue furin inhibitors derived from 4-amidinobenzylamide.

Philipps University Marburg

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

Philipps University Marburg

New furin inhibitors based on weakly basic amidinohydrazones.

Philipps University Marburg

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Philipps University Marburg

Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.

Philipps University Marburg

Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding.

Philipps University Marburg

Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.

Philipps University Marburg

Structure-based design and profiling of novel 17β-HSD14 inhibitors.

Philipps University Marburg

Thiazole orexin receptor antagonists

Merck Sharp & Dohme

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor

Schering-Plough Research Institute

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

National Health Research Institutes