PMID

Data

Article Title

Organization

2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase

Cancer Therapeutics Crc

Substituted tropane derivatives

Toa Eiyo

Dihydropyridinone MGAT2 inhibitors

Bristol-Myers Squibb

Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments

University of California

N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders

Ogeda

Aminoester derivatives

Chiesi Farmaceutici

Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them

Les Laboratoires Servier

Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds

Suzhou Zelgen Biopharmaceuticals

Indole carboxamide compounds

Bristol-Myers Squibb

Aminotriazine derivative and pharmaceutical composition comprising the same

Shionogi

Spirocyclic EBI2 modulators

Sanford Burnham Prebys Medical Discovery Institute

CDK inhibitors

G1 Therapeutics

[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof

Santen Pharmaceutical

Inhibitors of the Interaction of a Thyroid Hormone Receptor and Coactivators: Preliminary Structure-Activity Relationships.

St. Jude Research Hospital

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and a

Duquesne University

Insights into antifolate resistance from malarial DHFR-TS structures.

Mahidol University

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

National Center For Genetic Engineering and Biotechnology At Thailand

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors.

Pfizer

Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

Nci-Fcrdc

Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.

Gsk

Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors

Berlex Biosciences

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.

Merck Research Laboratories

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.

University of Dundee

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

University of Dundee

Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.

Elan Pharmaceuticals

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

Pfizer

Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.

Glaxosmithkline