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Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.

P. Angeletti S.P.A. (Merck Research Laboratories)

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

P. Angeletti S.P.A. (Merck Research Laboratories)

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

P. Angeletti S.P.A. (Merck Research Laboratories)