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Active site-directed plasmin inhibitors: Extension on the P2 residue.

Kobe Gakuin University

Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus.

Kobe Gakuin University

Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymeraseß.

Kobe Gakuin University

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.

Kobe Gakuin University

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.

Kobe Gakuin University

Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.

Kobe Gakuin University

Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Kobe Gakuin University

Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Kobe Gakuin University

Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.

Kobe Gakuin University

Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

Kobe Gakuin University

Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.

Kobe Gakuin University

New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.

Kobe Gakuin University

Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).

Kobe Gakuin University

Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.

Kobe Gakuin University

Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.

Kobe Gakuin University

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.

Kobe Gakuin University

Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines.

Kobe Gakuin University

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling.

Kobe Gakuin University

Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.

Kobe Gakuin University

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.

Kobe Gakuin University

Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.

Philipps University Marburg