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Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction.

Hokkaido University

Structure-activity relationship study of syringolin A as a potential anticancer agent.

Hokkaido University

Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.

Hokkaido University

Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor.

Hokkaido University

Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.

Hokkaido University

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.

Hokkaido University

Lipoxygenase inhibitors derived from marine macroalgae.

Hokkaido University

Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.

Hokkaido University

Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.

Hokkaido University

Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.

Hokkaido University

Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica.

Hokkaido University

Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.

Hokkaido University

Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases.

Hokkaido University

Synthesis of eudistomin D analogues and its effects on adenosine receptors.

Hokkaido University

2-Aminoresorcinol is a potent alpha-glucosidase inhibitor.

Hokkaido University

Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.

Hokkaido University

Rational design, synthesis, and characterization of novel inhibitors for human beta1,4-galactosyltransferase.

Hokkaido University

Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.

Hokkaido University

Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.

Hokkaido University

Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects.

Hokkaido University

Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.

Hokkaido University

A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.

Hokkaido University

Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors.

Hokkaido University

Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.

Hokkaido University

Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors.

Hokkaido University

Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.

Hokkaido University

An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

Hokkaido University

Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.

Hokkaido University

Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria.

Hokkaido University

Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.

Hokkaido University

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

Hokkaido University

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Hokkaido University

Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.

Hokkaido University

Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.

Hokkaido University

Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: cyclopropane-based conformationally restricted analogs of haloperidol.

Hokkaido University

Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis.

Hokkaido University

Mycophenolic acid as a latent agonist of PPARgamma.

Hokkaido University

Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

Hokkaido University

Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.

Hokkaido University

Synthesis of capuramycin and its analogues via a Ferrier-type I reaction and their biological evaluation.

Hokkaido University

A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.

Hokkaido University

Design, synthesis and conformation-activity relationship analysis of LNA/BNA-type 5'-O-aminoribosyluridine as MraY inhibitors.

Hokkaido University

Development of potent non-acylhydrazone inhibitors of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b).

Hokkaido University

Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.

Hokkaido University

Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum.

Hokkaido University

Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure.

Hokkaido University

Structural requirement of tunicamycin V for MraY inhibition.

Hokkaido University

Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice.

Hokkaido University

Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.

Hokkaido University

Design and synthesis of histamine H

Hokkaido University

Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.

Hokkaido University

Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.

Hokkaido University

Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.

Hokkaido University

Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.

Hokkaido University

Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2.

Hokkaido University

Spongiacidins A-D, new bromopyrrole alkaloids from hymeniacidon sponge

Hokkaido University

New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.

Hokkaido University

Ability of higenamine and related compounds to enhance glucose uptake in L6 cells.

Hokkaido University

Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors.

Hokkaido University

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1.

Johns Hopkins University