PMID

Data

Article Title

Organization

Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.

Hiroshima International University

Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.

Hiroshima International University

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.

Hiroshima International University

Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.

Hiroshima International University

Discovery of FXR/PPARγ dual partial agonist.

Hiroshima International University

Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum.

Hiroshima International University

N

Hiroshima International University

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

Hiroshima International University

Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity.

Hiroshima International University

Nonacidic Chemotype Possessing

Hiroshima International University