PMID

Data

Article Title

Organization

Synthesis, antinociceptive activity, and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols.

Glaxo Group Research

A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.

Glaxo Group Research

Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.

Glaxo Group Research

Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.

Glaxo Group Research

Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors.

Glaxo Group Research

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.

Glaxo Group Research

4-[(Alkylamino)methyl]furo[3,2-c]pyridines: a new series of selective kappa-receptor agonists.

Glaxo Group Research

Potent and highly selective neurokinin antagonists.

Glaxo Group Research

Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase.

Glaxo Group Research

New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus.

Glaxo Group Research

8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives

Idorsia Pharmaceuticals

Substituted boronic acids and boronate esters as immunoproteasome inhibitors

Merck Patent

Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity

Shionogi

Quinazoline derivative

Carna Biosciences

Ethynyl derivatives

Hoffmann-La Roche

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Wyeth Research