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99 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.EBI
Array Biopharma
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.EBI
Array Biopharma
Discovery of 2-pyridylureas as glucokinase activators.EBI
Array Biopharma
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.EBI
Array Biopharma
Discovery of 7-tetrahydropyran-2-yl chromans:ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloidß-protein (Aß) in the central nervous system.EBI
Array Biopharma
Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.EBI
Array Biopharma
Identification of a new class of glucokinase activators through structure-based design.EBI
Array Biopharma
Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species.EBI
Array Biopharma
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.EBI
Array Biopharma
Non-charged thiamine analogs as inhibitors of enzyme transketolase.EBI
Array Biopharma
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.EBI
Array Biopharma
Non-oxime pyrazole based inhibitors of B-Raf kinase.EBI
Array Biopharma
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.EBI
Array Biopharma
Discovery and SAR of spirochromane Akt inhibitors.EBI
Array Biopharma
Non-oxime inhibitors of B-Raf(V600E) kinase.EBI
Array Biopharma
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.EBI
Array Biopharma
Discovery of pyrrolopyrimidine inhibitors of Akt.EBI
Array Biopharma
Prodrug thiamine analogs as inhibitors of the enzyme transketolase.EBI
Array Biopharma
Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.EBI
Array Biopharma
Potent and selective mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors. 1. 4-(4-bromo-2-fluorophenylamino)-1- methylpyridin-2(1H)-ones.EBI
Array Biopharma
Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.EBI
Array Biopharma
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.EBI
Array Biopharma
Identification of the Clinical Development Candidate EBI
Array Biopharma
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.EBI
Array Biopharma
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.EBI
Array Biopharma
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.EBI
Array Biopharma
Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.EBI
Array Biopharma
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.EBI
Array Biopharma
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.EBI
Array Biopharma
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.EBI
Array Biopharma
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.EBI
Array Biopharma
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.EBI
Array Biopharma
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.EBI
Array Biopharma
ISOINDOLINES AS PMS2 INHIBITORSBDB
Neophore
Imidazopyridazine compounds and uses thereofBDB
Incyte
Pyrazine derivative and application thereof in inhibiting SHP2BDB
Suzhou Genhouse Pharmaceutical
Pyridone amides as modulators of sodium channelsBDB
Vertex Pharmaceuticals
Diazaindole derivative and use thereof as CHK1 inhibitorBDB
Medshine Discovery
Indole carboxamide compoundsBDB
Bristol-Myers Squibb
Certain chemical compositions and methods of use thereofBDB
Algen Biotechnologies
CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancerBDB
Amgen
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)BDB
Prelude Therapeutics
Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereofBDB
Landsteiner Genmed
Pyrrolopyrimidine and pyrrolopyridine derivativesBDB
Galapagos
Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disordersBDB
Bayer Aktiengesellschaft
Cyclic dinucleotides as sting agonistsBDB
Janssen Biotech
Compounds and uses thereofBDB
Kala Pharmaceuticals
Beta adrenergic agonist and methods of using the sameBDB
Curasen Therapeutics
Cannabinergic compounds and uses thereofBDB
Northeastern University
Heteroaromatic compounds as BTK inhibitorsBDB
Boehringer Ingelheim International
HDAC inhibitors for the treatment of diabetic peripheral neuropathyBDB
Regenacy Pharmaceuticals
2-(morpholin-4-yl)-1,7-naphthyridinesBDB
Bayer Pharma Aktiengesellschaft
2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitorsBDB
Almirall
Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitorsBDB
Xenon Pharmaceuticals
Benzimidazole derivatives as EP4 ligandsBDB
Bayer Pharma Aktiengesellschaft
Heterocyclic compounds for the treatment of diseaseBDB
Oppilan Pharma
Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitorsBDB
Sunovion Pharmaceuticals
TYK2 inhibitors and uses thereofBDB
Nimbus Lakshimi
Fused amino pyridine as HSP90 inhibitorsBDB
Curis
1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereofBDB
Shanghai Institute of Material Medica, Chinese Academy of Sciences
Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereofBDB
Jiangsu Hengrui Medicine
Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disordersBDB
Takeda Pharmaceutical
Inhibitors of matrix metalloproteinasesBDB
Pharmahungary 2000
6-alkynyl-pyridine derivativesBDB
Boehringer Ingelheim International
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.BDB
Shandong University
Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.BDB
Sun Yat-Sen University
CompoundsBDB
Respivert
Aminopyrimidine derivatives for use as modulators of kinase activityBDB
Merck Patent
Tetracyclic CDK9 kinase inhibitorsBDB
Abbvie
Small-Molecule Inhibitors of the SOX18 Transcription Factor.BDB
The University of Queensland
Pyrazole and imidazole derivatives useful as orexin antagonistsBDB
Actelion Pharmaceuticals
Heterocyclyl aminoimidazopyridazinesBDB
Bayer Intellectual Property
Pyridinones/pyrazinones, method of making, and method of use thereofBDB
Genentech
6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitorsBDB
Bayer Intellectual Property
Substituted pyrimidine compounds and their use as SYK inhibitorsBDB
Genosco
Methods and compositions for studying, imaging, and treating painBDB
The Leland Stanford Junior University
Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.BDB
Icahn School of Medicine At Mount Sinai
Tricyclic triazole compounds that modulate HSP90 activityBDB
Synta Pharmaceuticals
Chemical compoundsBDB
Astrazeneca
Radiolabeled PDE10A ligandsBDB
Abbvie
Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]ureaBDB
Vertex Pharmaceuticals
Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.BDB
Northeastern University
4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmeticsBDB
Galderma Research & Development
Discovery of novel tricyclic pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors.BDB
Suez Canal University
Ring-substituted N-pyridinyl amides as kinase inhibitorsBDB
Novartis
Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L.BDB
Smithkline Beecham Pharmaceuticals
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.BDB
Nagoya University School of Medicine
Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.BDB
Columbia University
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid.BDB
Istituto Di Chimica Biomolecolare
SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity.BDB
Ariad Pharmaceuticals
The discovery of novel vascular endothelial growth factor receptor tyrosine kinases inhibitors: pharmacophore modeling, virtual screening and docking studies.BDB
Shanghai Jiao Tong University
A structure-guided approach to creating covalent FGFR inhibitors.BDB
Harvard Medical School
Rational design, synthesis, and biological evaluation of progesterone-modified MRI contrast agents.BDB
Northwestern University
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).BDB
Merck Research Laboratories