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38229741

Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.

ACS Med Chem Lett 15: 6-8 (2024)

Therachem Research Medilab

2D SDF 3D SDF TSV

38229740

Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation.

ACS Med Chem Lett 15: 19-20 (2024)

Arrival Discovery

2D SDF 3D SDF TSV

38229748

Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.

ACS Med Chem Lett 15: 21-28 (2024)

Genentech

2D SDF 3D SDF TSV

38229750

Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC).

ACS Med Chem Lett 15: 29-35 (2024)

East China University of Science and Technology

2D SDF 3D SDF TSV

38229762

Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for

ACS Med Chem Lett 15: 36-44 (2024)

Jagiellonian University

2D SDF 3D SDF TSV

38229753

Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library.

ACS Med Chem Lett 15: 76-80 (2024)

Latvian Institute of Organic Synthesis

2D SDF 3D SDF TSV

38229744

Dual

ACS Med Chem Lett 15: 81-86 (2024)

Ghent University

2D SDF 3D SDF TSV

38229743

Chemical Catalysis Guides Structural Identification for the Major

ACS Med Chem Lett 15: 107-115 (2024)

Baylor College of Medicine

2D SDF 3D SDF TSV

38229758

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

ACS Med Chem Lett 15: 123-131 (2024)

Merck

2D SDF 3D SDF TSV

38229749

Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.

ACS Med Chem Lett 15: 132-142 (2024)

Chulabhorn Research Institute

2D SDF 3D SDF TSV

38352845

3-Alkynyl Carboxamides as AEP Modulators for Treating Alzheimer's Disease.

ACS Med Chem Lett 15: 159-160 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38352834

Novel PARP1 Inhibitors for Treating Cancer.

ACS Med Chem Lett 15: 161-162 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38352824

Emopamil-Binding Protein Inhibitors for Treating Multiple Sclerosis.

ACS Med Chem Lett 15: 163-164 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38352839

Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders.

ACS Med Chem Lett 15: 174-176 (2024)

Usona Institute

2D SDF 3D SDF TSV

38352847

Novel Fused Triazole Compounds as RIPK1 Inhibitors for Treating Neurodegenerative, Autoimmune, and Inflammatory Diseases.

ACS Med Chem Lett 15: 177-178 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38352830

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

ACS Med Chem Lett 15: 181-188 (2024)

Bristol-Myers Squibb Research & Development

2D SDF 3D SDF TSV

38352849

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

ACS Med Chem Lett 15: 189-196 (2024)

Bristol Myers Squibb

2D SDF 3D SDF TSV

38352833

Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.

ACS Med Chem Lett 15: 205-214 (2024)

University of Illinois At Chicago

2D SDF 3D SDF TSV

38352826

The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels.

ACS Med Chem Lett 15: 215-220 (2024)

University of Liege

2D SDF 3D SDF TSV

38352832

Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2.

ACS Med Chem Lett 15: 250-257 (2024)

University of Florence

2D SDF 3D SDF TSV

38352843

Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma.

ACS Med Chem Lett 15: 258-264 (2024)

Northwestern University

2D SDF 3D SDF TSV

38352842

Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP).

ACS Med Chem Lett 15: 270-279 (2024)

Nanjing University of Chinese Medicine

2D SDF 3D SDF TSV

38352850

Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists.

ACS Med Chem Lett 15: 302-309 (2024)

Vanderbilt University

2D SDF 3D SDF TSV

38505843

Novel Tetrahydropyrido[3,4-

ACS Med Chem Lett 15: 318-319 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38505855

Pyrrolidinone Derivatives as NIK Inhibitors for Treating Inflammatory and Autoimmune Diseases.

ACS Med Chem Lett 15: 322-323 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38505837

Novel AT2R Antagonists for Treating Chronic Pain.

ACS Med Chem Lett 15: 326-327 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38505847

Advancements in Predictive Medicine: NLRP3 Inflammasome Inhibitors and AI-Driven Predictive Health Analytics.

ACS Med Chem Lett 15: 331-333 (2024)

Usona Institute

2D SDF 3D SDF TSV

38505844

Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer.

ACS Med Chem Lett 15: 342-343 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38505842

Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain.

ACS Med Chem Lett 15: 355-361 (2024)

University of Zurich

2D SDF 3D SDF TSV

38505861

Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.

ACS Med Chem Lett 15: 381-387 (2024)

Janssen Pharmaceutical Research and Development

2D SDF 3D SDF TSV

38505838

Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists.

ACS Med Chem Lett 15: 413-417 (2024)

King'S College London

2D SDF 3D SDF TSV

38628791

The Science and Art of Structure-Based Virtual Screening.

ACS Med Chem Lett 15: 436-440 (2024)

Astrazeneca

2D SDF 3D SDF TSV

38628787

Novel Phosphorylpurinone Compounds for Treating Cancer.

ACS Med Chem Lett 15: 441-442 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38628783

Novel PCSK9 Inhibitors for Treating Cardiovascular Diseases.

ACS Med Chem Lett 15: 443-444 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38628789

Novel ACC Inhibitors for Treating Acne.

ACS Med Chem Lett 15: 445-446 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38628797

Novel Isoxazolidines as RIPK1 Inhibitors for Treating Alzheimer's Disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis.

ACS Med Chem Lett 15: 447-448 (2024)

Smith, Gambrell & Russell

2D SDF 3D SDF TSV

38628794

hERG,

ACS Med Chem Lett 15: 463-469 (2024)

University of Cape Town

2D SDF 3D SDF TSV

38628786

Discovery of a New Class of 1-(4-Sulfamoylbenzoyl)piperidine-4-carboxamides as Human Carbonic Anhydrase Inhibitors.

ACS Med Chem Lett 15: 470-477 (2024)

University of Cagliari

2D SDF 3D SDF TSV

38628803

Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.

ACS Med Chem Lett 15: 478-485 (2024)

Crinetics Pharmaceuticals

2D SDF 3D SDF TSV

38628796

Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.

ACS Med Chem Lett 15: 486-492 (2024)

Janssen Research and Development

2D SDF 3D SDF TSV

38628785

Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.

ACS Med Chem Lett 15: 501-509 (2024)

University of Nottingham

2D SDF 3D SDF TSV

38628788

Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability.

ACS Med Chem Lett 15: 510-517 (2024)

University of Nebraska Medical Center

2D SDF 3D SDF TSV

38628793

Design, Synthesis, and Evaluation of 8-(

ACS Med Chem Lett 15: 518-523 (2024)

Huaqiao University

2D SDF 3D SDF TSV

38628784

Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable

ACS Med Chem Lett 15: 524-532 (2024)

Sanders Tri-Institutional Therapeutics

2D SDF 3D SDF TSV

38628795

Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.

ACS Med Chem Lett 15: 533-539 (2024)

Whitman College

2D SDF 3D SDF TSV

38628800

In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).

ACS Med Chem Lett 15: 540-545 (2024)

Pfizer

2D SDF 3D SDF TSV