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TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | US8748451, 6 | Tubastatin A | US92...)
Affinity DataEC50:  145nMAssay Description:Inhibition of HDAC6 in mouse N2A cells assessed as increase in alpha tubulin acetylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM218202(US9249087, 43)
Affinity DataEC50:  932nMAssay Description:Inhibition of HDAC6 in mouse N2A cells assessed as increase in alpha tubulin acetylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50540612(CHEMBL4636622)
Affinity DataEC50:  250nMAssay Description:Inhibition of HDAC6 in mouse N2A cells assessed as increase in alpha tubulin acetylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 0.625nMAssay Description:Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreito...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM152481(Z-L-Am7(betaMe)-QA (3))
Affinity DataIC50: 3.20nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221738(CHEMBL1790595)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against histone deacetylases (HDAC) prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | US8748451, 6 | Tubastatin A | US92...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 in mouse N2A cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM152482((Z-L-Am7(S-)-QA)2 (4))
Affinity DataIC50: 7.5nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222728(cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) | CHEMBL3942...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50540612(CHEMBL4636622)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of HDAC6 in mouse N2A cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222735(cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) | CHEMBL39...)
Affinity DataIC50: 12nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50051031(CHEMBL2158745)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse HDAC6 expressed in HEK293T cells assessed as aminomethyl coumarin release using Ac-KGLGK(Ac)-MCA) substrate after 30 mins by FLIP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50366958(CHEMBL1790587)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against histone deacetylase 6 prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19136(tert-butyl N-[(1S)-1-(cycloheptylcarbamoyl)-6-sulf...)
Affinity DataIC50: 23nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222736(cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) | CHEMBL...)
Affinity DataIC50: 24nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222733(cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) | CHEMBL39396...)
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 28nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against histone deacetylase 6 prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19134(CHEMBL213934 | tert-butyl N-[(1S)-1-(cyclopentylca...)
Affinity DataIC50: 29nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM152480(Z-L-Am7(AcEtMe)-QA (2))
Affinity DataIC50: 29nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222737(cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) | CHEMBL23858...)
Affinity DataIC50: 29nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50366966(CHEMBL1790596)
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against histone deacetylase 6 prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19133(tert-butyl N-[(1S)-1-(quinolin-3-ylcarbamoyl)-6-su...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222726(cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) | CHEMBL39...)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM152479(Z-L-Am7(Ac)-QA (1))
Affinity DataIC50: 34nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19135(CHEMBL209551 | tert-butyl N-[(1S)-1-(cyclohexylcar...)
Affinity DataIC50: 36nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222738(cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) | CHEMBL39138...)
Affinity DataIC50: 36nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222732(cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) | (5S,11S,13a...)
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19131(CHEMBL419758 | N-(4-phenyl-1,3-thiazol-2-yl)-7-sul...)
Affinity DataIC50: 41nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222727((5S,11S,13aR)-5,8,8-trimethyl-11-[5-(pyridin-2-yld...)
Affinity DataIC50: 43nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222729(cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) | CHEMBL39138...)
Affinity DataIC50: 43nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50460520(CHEMBL4228293)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50200895((S)-benzyl 8-(hydroxyamino)-1,8-dioxo-1-(quinolin-...)
Affinity DataIC50: 45nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM218202(US9249087, 43)
Affinity DataIC50: 46nMAssay Description:Inhibition of HDAC6 in mouse N2A cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50460521(CHEMBL4228332)
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19132(tert-butyl N-[(1S)-1-[(3-phenylphenyl)carbamoyl]-6...)
Affinity DataIC50: 54nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50558325(CHEMBL4746359)
Affinity DataIC50: 55nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222730(cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) | CHEMBL...)
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 65nMAssay Description:Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19137(tert-butyl N-[(1S)-1-(tert-butylcarbamoyl)-6-sulfa...)
Affinity DataIC50: 71nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222731(cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) | CHEMBL...)
Affinity DataIC50: 71nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19148(benzyl N-[(1S)-1-(cyclopentylcarbamoyl)-6-sulfanyl...)
Affinity DataIC50: 78nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 81nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50460518(CHEMBL4228977)
Affinity DataIC50: 81nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19138(tert-butyl N-[(1S)-1-(adamantan-1-ylcarbamoyl)-6-s...)
Affinity DataIC50: 82nMpH: 8.0 T: 2°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50048862(CHEMBL3310510)
Affinity DataIC50: 83nMAssay Description:Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreito...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366962(CHEMBL1790586)
Affinity DataIC50: 84nMAssay Description:Inhibitory activity against histone deacetylases (HDAC) prepared from mouse melanoma B16/BL6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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