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Report error Found 3057 for UniProtKB: Q9UQL6
TargetHistone deacetylase 5(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137826(8-Biphenyl-4-yl-8-oxo-octanoic acid (2-amino-pheny...)
Affinity DataEC50:  1.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137843(8-Biphenyl-3-yl-8-oxo-octanoic acid (2-amino-pheny...)
Affinity DataEC50:  2.50E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137828(6-(5-Hydroxy-6-morpholin-4-ylmethyl-1,3-dioxo-1H,3...)
Affinity DataEC50:  2.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137838(6-(6-Bromo-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137832(8-Naphthalen-2-yl-8-oxo-octanoic acid (2-amino-phe...)
Affinity DataEC50:  2.50E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137835(8-(4-Bromo-phenyl)-8-oxo-octanoic acid (2-amino-ph...)
Affinity DataEC50:  1.50E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137829(6-(5-Hydroxy-1,3-dioxo-1H,3H-benzo[de]isoquinolin-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137850(6-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-y...)
Affinity DataEC50: >2.50E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137827(8-Oxo-8-phenyl-octanoic acid (2-amino-phenyl)-amid...)
Affinity DataEC50:  2.50E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137831(8-Oxo-8-(6-phenyl-pyridin-3-yl)-octanoic acid (2-a...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137839(6-(5-Hydroxy-1,3-dioxo-6-piperidin-1-ylmethyl-1H,3...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137837(8-Oxo-8-(4-pyridin-3-yl-phenyl)-octanoic acid (2-a...)
Affinity DataEC50:  2.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137841(6-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-yl)-hexanoic ...)
Affinity DataEC50:  1.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137846(6-(4-Oxo-4H-quinazolin-3-yl)-hexanoic acid (2-amin...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137845(6-(5-Methyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-h...)
Affinity DataEC50:  3.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137836(8-(3',4'-Dimethoxy-biphenyl-4-yl)-8-oxo-octanoic a...)
Affinity DataEC50:  3.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137830(6-(5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137844(6-(1-Oxo-1,3-dihydro-isoindol-2-yl)-hexanoic acid ...)
Affinity DataEC50:  9.90E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137842(8-(4-Methoxy-phenyl)-8-oxo-octanoic acid (2-amino-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137848(6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-hexanoic a...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137849(6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexa...)
Affinity DataEC50:  3.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50137834(6-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-hexan...)
Affinity DataEC50:  1.00E+4nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effect on induced hyperacetylation of histones in whole cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataEC50:  180nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataEC50:  30nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50465051(CHEMBL4285950)
Affinity DataEC50:  350nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483539(CHEMBL1688184)
Affinity DataEC50:  30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483540(CHEMBL1688186)
Affinity DataEC50:  190nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483541(CHEMBL1688187)
Affinity DataEC50:  460nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483542(CHEMBL1688190)
Affinity DataEC50:  390nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483543(CHEMBL1688191)
Affinity DataEC50:  340nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483544(CHEMBL1688192)
Affinity DataEC50:  6.24E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483545(CHEMBL1688194)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483546(CHEMBL1688195)
Affinity DataEC50:  2.65E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483539(CHEMBL1688184)
Affinity DataEC50:  60nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483541(CHEMBL1688187)
Affinity DataEC50:  430nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483547(CHEMBL1688189)
Affinity DataEC50:  720nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483542(CHEMBL1688190)
Affinity DataEC50:  280nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483544(CHEMBL1688192)
Affinity DataEC50:  3.27E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483545(CHEMBL1688194)
Affinity DataEC50:  1.53E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483547(CHEMBL1688189)
Affinity DataEC50:  500nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483540(CHEMBL1688186)
Affinity DataEC50:  150nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483546(CHEMBL1688195)
Affinity DataEC50:  2.95E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483548(CHEMBL1688185)
Affinity DataEC50:  200nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483549(CHEMBL1688188)
Affinity DataEC50:  840nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483550(CHEMBL1688183)
Affinity DataEC50:  90nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483549(CHEMBL1688188)
Affinity DataEC50:  860nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483543(CHEMBL1688191)
Affinity DataEC50:  360nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase(Human)
Methylgene

Curated by ChEMBL
LigandPNGBDBM50483550(CHEMBL1688183)
Affinity DataEC50:  30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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