Affinity DataEC50: 480nMAssay Description:Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate rea...More data for this Ligand-Target Pair
Affinity DataEC50: 1.25E+3nMAssay Description:Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate rea...More data for this Ligand-Target Pair
Affinity DataEC50: 7.60nMAssay Description:Agonist activity at human TRPC5 stably expressed in HEK293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate reader...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 1/5(Human)
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human TRPC5/human TRPC1 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fl...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of human TRPC5 expressed in human T-REx-293 cells assessed as reduction in lanthanum-activated TRPC5-mediated currents by whole-cell patch...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.84nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.52nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 7.37nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human TRPC5 expressed in human T-REx-293 cells assessed as reduction in calcium influx by Fluo-4AM dye based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10.8nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked channel current measured at +80 mV by whole-cell volt...More data for this Ligand-Target Pair
Affinity DataIC50: 14.6nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 15.7nMpH: 7.2Assay Description:TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
Affinity DataIC50: 18.2nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:TRPC5 is a type of non-selective cation channel with permeability to calcium ions. Therefore, TRPC5 agonist Englerin A (EA) and TRPC5 inhibitor Pico1...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 8...More data for this Ligand-Target Pair
