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Report error Found 83 of affinity data for UniProtKB/TrEMBL: Q9UGI6
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50618501(CHEMBL5403198)
Affinity DataEC50:  200nMAssay Description:Activation of SK3 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  1.50E+4nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561183(CHEMBL4787693)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50426576(CHEMBL2324346)
Affinity DataEC50:  20nMAssay Description:Inhibition of human Kca 2.3 expressed in HEK293 cells by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataKd:  100nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  400nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561184(CHEMBL4762592)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561186(CHEMBL4760396)
Affinity DataEC50:  3.80nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561185(CHEMBL4749661)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561185(CHEMBL4749661)
Affinity DataEC50:  0.360nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as reduction in channel current with holding potential 0 mV and ramp voltage ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataEC50:  1.81E+3nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263331((1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaph...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of wild type human SK3 channel expressed in HEK293 cells assessed as Ca2+ sensitivity by inside-out patch clamp technique in presence of 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  7.80nMAssay Description:Inhibition of human SK3 channel expressed in HEK293 cells assessed as Ca2+ induced current after drug wash out by whole cell patch clamp technique in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  60nMAssay Description:Inhibition of human SK3 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275157(N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-me...)
Affinity DataEC50:  5.60E+3nMAssay Description:Positive modulation of SK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561187(CHEMBL4786321)
Affinity DataEC50:  2.60nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as reduction in channel current with holding potential 0 mV and ramp voltage ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50561188(CHEMBL4785313)
Affinity DataEC50:  0.380nMAssay Description:Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as reduction in channel current with holding potential 0 mV and ramp voltage ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50583211(CHEMBL5078247)
Affinity DataEC50:  190nMAssay Description:Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology relative ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50583213(CHEMBL5086997)
Affinity DataEC50:  600nMAssay Description:Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275183(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Affinity DataEC50:  5.89E+5nMAssay Description:Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataEC50:  900nMAssay Description:Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50618500(CHEMBL5421015)
Affinity DataEC50:  140nMAssay Description:Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50260153(Octadecapeptide venom | Apamin | CHEMBL525408)
Affinity DataIC50: 0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50435962(CHEMBL2391655)
Affinity DataIC50: 31nMAssay Description:Inhibition of KCa2.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 56nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 59nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50150389(17,23-diazonia-2,9-diazahexacyclo[21.6.2.24,7.210,...)
Affinity DataIC50: 60nMAssay Description:Inhibition of KCa2.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 290nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 543nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 580nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275958((R)-5-chloro-N-(1-phenylethyl)pyrazolo[1,5-a]pyrim...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50048403(dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniu...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50048403(dequalinium | 1-[10-(4-amino-2-methyl-1-quinoliniu...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of cloned human SK3 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of SK3 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275798(5-chloro-N-(3-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275959(5-chloro-N-(1,2-diphenylethyl)pyrazolo[1,5-a]pyrim...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275853(5-chloro-N-(3-nitrobenzyl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275797(5-chloro-N-(2-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275850(5-chloro-N-(3-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275852(5-chloro-N-(3-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275851(5-chloro-N-(3-(trifluoromethyl)benzyl)pyrazolo[1,5...)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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