Compile Data Set for Download or QSAR
Report error Found 13 of affinity data for UniProtKB/TrEMBL: Q92952
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  54nMAssay Description:Inhibition of human SK1 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50: >1.00E+5nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

LigandPNGBDBM50275183(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Affinity DataEC50:  6.50E+5nMAssay Description:Positive modulation of SK1 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataEC50:  600nMAssay Description:Positive modulation of SK1 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50618500(CHEMBL5421015)
Affinity DataEC50: >1.00E+5nMAssay Description:Positive modulation of SK1 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50275157(N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-me...)
Affinity DataEC50: >1.00E+5nMAssay Description:Positive modulation of SK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50092131(CHEMBL612120 | UCL-1848 | CHEMBL420873 | 1,7-diazo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel); Range is 1-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 43nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of SK1 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed