Compile Data Set for Download or QSAR
Report error Found 14 of affinity data for UniProtKB/TrEMBL: Q8SPZ1
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50122654(sufugolix | TAK-013 | 1-{4-[5-[(Benzyl-methyl-amin...)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50291734(CHEMBL4159247)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cell membranes incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50291733(CHEMBL4173065)
Affinity DataIC50: 3.80nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50067485(CHEMBL544440 | 3-[(Benzyl-methyl-amino)-methyl]-7-...)
Affinity DataIC50: 4nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50291735(CHEMBL4169891)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]D-Trp6-LHRH from monkey GnRH receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50098391(4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5...)
Affinity DataIC50: 7nMAssay Description:Activity at rhesus monkey GnRH receptor by inositol phosphate functional assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50533858(CHEMBL4449332)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against monkey GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50533863(CHEMBL4593521)
Affinity DataIC50: 32nMAssay Description:Antagonist activity against monkey GnRH receptor expressed in HEK293 cells co-transfected with pGL4-NFAT promoter AP1-luc assessed as inhibition of 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50098391(4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274930((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from monkey GnRH receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007(3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity at monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rhesus macaque)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50162007(3-[(2R)-amino-2-phenylethyl]-1-(2,6-difluorobenzyl...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from monkey GnRH receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed