Compile Data Set for Download or QSAR
Report error Found 14 of affinity data for UniProtKB/TrEMBL: Q8BRU6
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 3.39nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459621(CHEMBL4202787)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459630(CHEMBL4207658)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459627(CHEMBL4208779)
Affinity DataIC50: 13nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459619(CHEMBL4206824)
Affinity DataIC50: 20nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459626(CHEMBL4214975)
Affinity DataIC50: 25nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50459628(CHEMBL4208250)
Affinity DataIC50: 32nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50192902(Ro-4-1284 | 2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,...)
Affinity DataIC50: 50nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 98nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataIC50: 100nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataIC50: 381nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Mouse)
Organix

Curated by ChEMBL
LigandPNGBDBM50009057(METHAMPHETAMINE (+) | Methyl-(1-methyl-2-phenyl-et...)
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed