Compile Data Set for Download or QSAR
Report error Found 90 of affinity data for UniProtKB/TrEMBL: Q6QIY3
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to mouse Nav1.8 TTX-resistant current by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to mouse Nav1.8 TTX-resistant current by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329205(5-(4-chlorophenyl)-N-((2-(piperidin-1-yl)pyridin-3...)
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329209(5-(4-chlorophenyl)-N-(2-(piperidin-1-yl)benzyl)nic...)
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329211(5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide ...)
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231774(5-(4-chlorophenyl)-N-cyano-N'-(3-methylphenyl)fura...)
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329208(5-(4-chlorophenyl)-N-(2-morpholinobenzyl)nicotinam...)
Affinity DataIC50: 32nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330949(N-(3,5-Dimethylphenyl)-6-(4-ethoxyphenyl)-pyrazine...)
Affinity DataIC50: 56nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329217(N-(2-Methylbenzyl)-6-(4-trifluoromethoxyphenyl)-py...)
Affinity DataIC50: 57nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329217(N-(2-Methylbenzyl)-6-(4-trifluoromethoxyphenyl)-py...)
Affinity DataIC50: 58nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330945(N-(m-Tolyl)-6-(4-trifluoromethoxyphenyl)-pyrazine-...)
Affinity DataIC50: 66nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329210(N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide ...)
Affinity DataIC50: 81nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329203(5-(4-chlorophenyl)-N-((2-(2,2,2-trifluoroethoxy)py...)
Affinity DataIC50: 87nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329206(5-(4-chlorophenyl)-N-((2-ethoxypyridin-3-yl)methyl...)
Affinity DataIC50: 88nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330948(N-(2-Methylbenzyl)-6-(4-ethoxyphenyl)-pyrazine-2-c...)
Affinity DataIC50: 110nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329202(5-(4-cyanophenyl)-N-(3,5-dimethylphenyl)nicotinami...)
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330934(N-((2-Pyrrolidin-1-yl-pyridin-3-yl)methyl)-6-(4-ch...)
Affinity DataIC50: 210nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330942(N-(2-methylbenzyl)-6-(4-(trifluoromethoxy)phenyl)p...)
Affinity DataIC50: 240nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329218(N-(3,5-dimethylphenyl)-5-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 280nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231777(5-[(4-trifluoromethoxy)phenyl]-N-(3-methylphenyl)f...)
Affinity DataIC50: 290nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329223(N-(3,5-dimethylphenyl)-5-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 290nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329204(5-(4-chlorophenyl)-N-((2-morpholinopyridin-3-yl)me...)
Affinity DataIC50: 340nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329222(N-(3,5-dimethylphenyl)-2-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 340nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329219(N-(3,5-dimethylphenyl)-2-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 400nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50371254(CHEMBL429830)
Affinity DataIC50: 430nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330944(N-(3,5-Dimethylphenyl)-6-(4-cyanophenyl)-pyrazine-...)
Affinity DataIC50: 470nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231767(5-(4-cyanophenyl)-N-(3-methylphenyl)furan-2-carbox...)
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231779(5-(4-chlorophenyl)-N-(3-methylphenyl)furan-2-carbo...)
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330932(N-((2-Morpholin-4-yl-pyridin-3-yl)methyl)-6-(4-cya...)
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330933(N-(3,5-Dimethylphenyl)-6-(4-chlorophenyl)-pyrazine...)
Affinity DataIC50: 490nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329215(N-(3,5-dimethylphenyl)-5-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 530nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329213(5-(4-chlorophenyl)-N-(3,5-dimethylphenyl)nicotinam...)
Affinity DataIC50: 610nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329212(N-benzyl-5-(4-chlorophenyl)nicotinamide | CHEMBL12...)
Affinity DataIC50: 620nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330935(N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyrazine-2-carboxam...)
Affinity DataIC50: 650nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329207(5-(4-chlorophenyl)-N-((2-chloropyridin-3-yl)methyl...)
Affinity DataIC50: 680nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330936(6-(4-cyanophenyl)-N-(3-isopropoxyphenyl)pyrazine-2...)
Affinity DataIC50: 730nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50: 850nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329220(N-(3,5-dimethylphenyl)-3-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 870nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270682(5-(4-Chlorophenyl)furan-2-carboxylic acid-(2-piper...)
Affinity DataIC50: 900nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231770(5-(4-chlorophenyl)-N-[(5-methyl)pyridin-3-yl]furan...)
Affinity DataIC50: 960nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330937(N-(m-Tolyl)-6-(4-chlorophenyl)-pyrazine-2-carboxam...)
Affinity DataIC50: 960nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50371245(CHEMBL399792)
Affinity DataIC50: 970nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270679([5-(4-Chlorophenyl)furan-2-yl]-(4-cyclohexylpipera...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330940(N-((2-Chloropyridin-3-yl)methyl)-6-(4-(trifluorome...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330941(N-(3,5-Dimethoxyphenyl)-6-(4-chlorophenyl)-pyrazin...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50371253(CHEMBL427714)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50330943(N-(2-Methylbenzyl)-6-(4-chlorophenyl)-pyrazine-2-c...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329221(N-(3,5-dimethylphenyl)-2-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50329216(N-(3,5-dimethylphenyl)-6-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse NaV1.8 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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