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TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50: 700nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206065(N-{2-[1-(3-methoxy-benzyl)-piperidin-4-ylamino]-be...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206073(N-[2-(2-pyridin-2-yl-ethylamino)-benzothiazol-6-yl...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523390(CHEMBL4584061)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50365330(CHEMBL1956107)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of rat recombinant eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206066(N-(2-{1-[2-(3H-imidazol-4-yl)-ethyl]-piperidin-4-y...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206068(N-(2-{1-[2-(4-Bromo-phenyl)-ethyl]-piperidin-4-yla...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206070(N-[2-(2-morpholin-4-yl-ethylamino)-benzothiazol-6-...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50206064(N-[2-(1-benzyl-piperidin-4-ylamino)-benzothiazol-6...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523384(CHEMBL4459416)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523372(CHEMBL4538398)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523387(CHEMBL4556281)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523388(CHEMBL4556575)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523380(CHEMBL4586157)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523374(CHEMBL4472570)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523373(CHEMBL4552440)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523391(CHEMBL4449083)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523385(CHEMBL4475391)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523379(CHEMBL4467355)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523375(CHEMBL4555818)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523382(CHEMBL4563209)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523378(CHEMBL4556372)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523386(CHEMBL4541558)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523389(CHEMBL4559477)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523383(CHEMBL4438120)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50265253((S)-2-amino-3-(1H-indol-3-yl)-N-(2-(1,2,3,4-tetrah...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50099602(CHEMBL3343931)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523377(CHEMBL4559593)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523371(CHEMBL4456435)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523381(CHEMBL4444822)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523393(CHEMBL4466307)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50523392(CHEMBL4582203)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50379737(CHEMBL2011128)
Affinity DataIC50: 6.26E+4nMAssay Description:Inhibition of rat eNOSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  16nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM190668(nNOS inhibitor, 6 | US10759791, Compound 14k)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US9951014, Name 6 | US10759791, Co...)
Affinity DataKi:  35nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM190665(nNOS inhibitor, 3 | US10759791, Compound 14g)
Affinity DataKi:  43nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM190666(nNOS inhibitor, 4 | US10759791, Compound 14h)
Affinity DataKi:  72nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50180872(CHEMBL3819046 | US10759791, Compound 14a)
Affinity DataKi:  139nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNitric oxide synthase, endothelial(Rat)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50180871(CHEMBL3819644 | US10759791, Compound 14c)
Affinity DataKi:  547nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent