Compile Data Set for Download or QSAR
Report error Found 437 for UniProtKB: Q15369
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50463158(CHEMBL4244103)
Affinity DataKd:  5nMAssay Description:Binding affinity to N-terminal His6 tagged VHL (54 to 213 residues)/ELoC (17 to 112 residues)/EloB (1 to 120 residues) (unknown origin) complex expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50463159(CHEMBL4241500)
Affinity DataKd:  6.70nMAssay Description:Binding affinity to N-terminal His6 tagged VHL (54 to 213 residues)/ELoC (17 to 112 residues)/EloB (1 to 120 residues) (unknown origin) complex expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50647304(CHEMBL5184620)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of 6xHis-tagged VHL (1 to 213 residues)/Elongin B/Elogin C (unknown origin) expressed in Escherichia coli BL21 cells by fluorescence polar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  16nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  24nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 10 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615674(CHEMBL5274606)
Affinity DataKd:  24nMAssay Description:Binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant using FA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataKd:  25nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615675(CHEMBL5182441)
Affinity DataKd:  26nMAssay Description:Binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by ITC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615675(CHEMBL5182441)
Affinity DataKd:  27nMAssay Description:Negative co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissocia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
LigandPNGBDBM536223(US11242344, Example 129.4 | (2R)-1-((2S,4R)-4-hydr...)
Affinity DataKd:  29.3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615674(CHEMBL5274606)
Affinity DataKd:  33nMAssay Description:Binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by ITC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50646619(CHEMBL5592905)
Affinity DataKd:  34nMAssay Description:Binding affinity to human VHL (54 to 213 residues)/Elongin B (1 to104 residues)/Elongin C (17 to 112 residues) assessed as dissociation constant meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628960(CHEMBL5425050)
Affinity DataKd:  34nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615675(CHEMBL5182441)
Affinity DataKd:  35nMAssay Description:Co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation cons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615675(CHEMBL5182441)
Affinity DataKd:  35nMAssay Description:Binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant using FA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataKd:  37nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50646618(CHEMBL5595966)
Affinity DataKd:  37nMAssay Description:Binding affinity to human VHL (54 to 213 residues)/Elongin B (1 to104 residues)/Elongin C (17 to 112 residues) assessed as dissociation constant meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50590279(CHEMBL4740486)
Affinity DataKi:  39nMAssay Description:Displacement of (2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide from dual VBC E3 ligase (unknown origin) te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628963(CHEMBL5403921)
Affinity DataKd:  41nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628957(CHEMBL5405990)
Affinity DataKd:  41nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM536223(US11242344, Example 129.4 | (2R)-1-((2S,4R)-4-hydr...)
Affinity DataKd:  43.8nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628964(CHEMBL5425778)
Affinity DataKd:  44nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459943(CHEMBL4225470)
Affinity DataKd:  44nMAssay Description:Binding affinity to VHL (unknown origin)/elongin C (unknown origin)/elongin B (unknown origin) by isothermal titration calorimetry-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628962(CHEMBL5398197)
Affinity DataKd:  45nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560814(US11389438, # 54)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560701(US11389438, # 11)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560818(US11389438, # 58)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560712(US11389438, # 44)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560809(US11389438, # 45)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560711(US11389438, # 43)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560812(US11389438, # 48)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560810(US11389438, # 46)
Affinity DataKd: <50nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataKd:  52nMAssay Description:Binding affinity to VBC (unknown origin) at 50 uM at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628963(CHEMBL5403921)
Affinity DataKd:  53nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50604004(CHEMBL5205396)
Affinity DataKd:  56nMAssay Description:Binding affinity to VCB E3 ligase (unknown origin) assessed as binary equilibrium dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615676(CHEMBL5274502)
Affinity DataKd:  60nMAssay Description:Co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation cons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50646620(CHEMBL5592812)
Affinity DataKd:  62nMAssay Description:Binding affinity to human VHL (54 to 213 residues)/Elongin B (1 to104 residues)/Elongin C (17 to 112 residues) assessed as dissociation constant meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM536252(BDBM536273 | (2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-...)
Affinity DataIC50: 62.8nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent

TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628964(CHEMBL5425778)
Affinity DataKd:  63nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628958(CHEMBL5412800)
Affinity DataKd:  66nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459880(CHEMBL4226570)
Affinity DataKd:  69nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human VHL (54 to 213 residues)/elongin C (17 to 112 residues)/elongin B (1 to 104 residues) ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615676(CHEMBL5274502)
Affinity DataKd:  70nMAssay Description:Binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant using FA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628959(CHEMBL5422221)
Affinity DataKd:  72nMAssay Description:Binding affinity to biotinylated VHL/Elongin B/Elongin C (unknown origin) immobilized in SA sensor chip assessed as dissociation constant by SPR anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50628962(CHEMBL5398197)
Affinity DataKd:  73nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50459879(CHEMBL4227226)
Affinity DataKd:  73nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human VHL (54 to 213 residues)/elongin C (17 to 112 residues)/elongin B (1 to 104 residues) ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetElongin-C(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615674(CHEMBL5274606)
Affinity DataKd:  73nMAssay Description:Negative co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as dissocia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560816(US11389438, # 56)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560702(US11389438, # 20)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560817(US11389438, # 57)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetVHL complex(Human)
Chdi Foundation

US Patent
LigandPNGBDBM560703(US11389438, # 21)
Affinity DataKd:  75nMAssay Description:Surface Plasmon Resonance (SPR) assays have been developed to test the affinity (KD) of VHL or CRBN-based compounds to respective recombinant ligase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

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